The overall theme of my research is concentrated in applying computational modeling and non-invasive imaging methodologies to explore the nature of soft-tissue mechanics in cancer and development, with an emphasis on driving clinical therapeutic interventions. My research focuses on the multi-disciplinary study of the multi-scale influences of mechanics in cancer progression and response to therapy, involving the development and validation of image-based mathematical modeling approaches to evaluate quantitative parameterization of cancer properties and predict the response to therapy.