{"id":6,"date":"2011-08-25T20:20:59","date_gmt":"2011-08-26T01:20:59","guid":{"rendered":"https:\/\/my.vanderbilt.edu\/alissaweaver\/publications\/"},"modified":"2022-07-14T16:40:32","modified_gmt":"2022-07-14T21:40:32","slug":"publications","status":"publish","type":"page","link":"https:\/\/my.vanderbilt.edu\/alissaweaver\/?page_id=6","title":{"rendered":"Publications"},"content":{"rendered":"

Research Articles
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Salomon Carlos , Das Saumya , Erdbr\u00fcgger Uta , Kalluri Raghu , Lim Kiang , Olefsky M , Rice E , Sahoo Susmita , Tao Andy , Vader Pieter , Wang Qun , Weaver M , Extracellular Vesicles and Their Emerging Roles as Cellular Messengers in Endocrinology: An Endocrine Society Scientific Statement Endocr Rev. 2022 Apr 21;\u00a0PMID: 35446389 [PubMed].<\/a><\/p>\n

Barman B, Sung BH, Krystofiak E, Ping J, Ramirez M, Millis B, Allen R, Prasad N, Chetyrkin S, Calcutt MW, Vickers K, Patton JG, Liu Q, Weaver AM. VAP-A and its binding partner CERT drive biogenesis of RNA-containing extracellular vesicles at ER membrane contact sites. Dev Cell. 2022 Apr 25;57(8):974-994.e8. doi: 10.1016\/j.devcel.2022.03.012. Epub 2022 Apr 13. PMID: 35421371; PMCID: PMC9075344.<\/a><\/p>\n

Abner JJ, Franklin JL, Clement MA, Hinger SA, Allen RM, Liu X, Kellner S, Wu J, Karijolich J, Liu Q, Vickers KC, Dedon P, Weaver AM, Coffey RJ, Patton JG. Depletion of METTL3 alters cellular and extracellular levels of miRNAs containing m6<\/sup>A consensus sequences. Heliyon. 2021 Dec 2;7(12):e08519. doi: 10.1016\/j.heliyon.2021.e08519. PMID: 34934837; PMCID: PMC8654799.<\/a><\/p>\n

Lim AR, Vincent BG, Weaver AM, Rathmell WK. Sunitinib and Axitinib increase secretion and glycolytic activity of small extracellular vesicles in renal cell carcinoma. Cancer Gene Ther. 2021 Jun 4:10.1038\/s41417-021-00345-1. doi: 10.1038\/s41417-021-00345-1. Epub ahead of print. PMID: 34088993; PMCID: PMC8642495.<\/a><\/p>\n

Patel MR, Weaver AM. Astrocyte-derived small extracellular vesicles promote synapse formation via fibulin-2-mediated TGF-\u03b2 signaling. Cell Rep. 2021 Mar 9;34(10):108829. doi: 10.1016\/j.celrep.2021.108829. PMID: 33691102; PMCID: PMC8002899.<\/a><\/p>\n

Huang C, Chen L, Savage SR, et al. Clinical Proteomic Tumor Analysis Consortium. Proteogenomic insights into the biology and treatment of HPV-negative head and neck squamous cell carcinoma. Cancer Cell. 2021 Mar 8;39(3):361-379.e16. doi: 10.1016\/j.ccell.2020.12.007. Epub 2021 Jan 7. PMID: 33417831; PMCID: PMC7946781.<\/a><\/p>\n

Altei WF, Pachane BC, Dos Santos PK, Ribeiro LNM, Sung BH, Weaver AM, Selistre-de-Ara\u00fajo HS. Inhibition of \u03b1v\u03b23 integrin impairs adhesion and uptake of tumor-derived small extracellular vesicles. Cell Commun Signal. 2020 Sep 25;18(1):158. doi: 10.1186\/s12964-020-00630-w. PMID: 32988382; PMCID: PMC7520983.<\/a><\/p>\n

Harris LA, Beik S, Ozawa PMM, Jimenez L, Weaver AM. Modeling heterogeneous tumor growth dynamics and cell-cell interactions at single-cell and cell-population resolution. Curr Opin Syst Biol. 2019 Oct;17:24-34. doi: 10.1016\/j.coisb.2019.09.005. Epub 2019 Sep 16. PMID: 32642602; PMCID: PMC7343346<\/a>.<\/p>\n

Sung BH, von Lersner A, Guerrero J, Krystofiak ES, Inman D, Pelletier R, Zijlstra A, Ponik SM, Weaver AM. A live cell reporter of exosome secretion and uptake reveals pathfinding behavior of migrating cells. Nat Commun. 2020 Apr 29;11(1):2092. doi: 10.1038\/s41467-020-15747-2. PMID: 32350252; PMCID: PMC7190671.<\/a><\/p>\n

Weaver AM, Patton JG. Argonautes in Extracellular Vesicles: Artifact or Selected Cargo? Cancer Res. 2020 Feb 1;80(3):379-381. doi: 10.1158\/0008-5472.CAN-19-2782. Epub 2019 Nov 29. PMID: 31784424; PMCID: PMC7002258.<\/a><\/p>\n

Barman, B, Ping, J, Krystofiak, E, Allen, R, Prasad, N, Vickers, K, Patton, JG, Liu, Q, and Weaver, AM, \u201cBiogenesis of RNA-containing extracellular vesicles at endoplasmic reticulum membrane contact sites.\u201d\u00a0 https:\/\/www.biorxiv.org\/content\/10.1101\/2020.12.04.412379v1<\/a><\/p>\n

Sato S, Vasaikar S, Eskaros A, et al. EPHB2 carried on small extracellular vesicles induces tumor angiogenesis via activation of ephrin reverse signaling. JCI Insight. 2019;4(23)\u00a0PMCID: 31661464<\/a><\/p>\n

Jimenez L, Yu H, Mckenzie A, Franklin JL, Patton JG, Liu Q, and Weaver AM “Quantitative proteomic analysis of small and large extracellular vesicles (EVs) reveals enrichment of adhesion proteins in small EVs.” J Proteome Res.<\/span> 2019; PMCID: 30608700<\/a><\/p>\n

Sung, BH and AM Weaver, “Exosome secretion promotes chemotaxis of cancer cells\u201d\u00a0Cell Adhesion & Migration, 11:187-195, 2017. PMCID: 5351719<\/a><\/p>\n

Sinha, S, Hoshino, D, Hong, NH, Kirkbride, KC, Grega-Larson, N, Seiki, M, Tyska, MJ, and Weaver AM, “Cortactin promotes exosome secretion by controlling branched actin dynamics.” J. Cell Biol.<\/span>, 214:197-213,2016. PMCID: PMC4949450<\/a><\/p>\n

McKenzie, AJ, Hoshino, D, Hong, NH, Cha, DJ, Franklin, JL, Coffey, RJ, Patton, JG, and Weaver AM, “Kras-Mek signaling controls ago2 sorting into exosomes”, Cell Reports<\/span>, 15:978-987, 2016. PMCID: PMC4857875<\/a><\/p>\n

Koshikawa, N, Hoshino, D, Taniguchi, H, Minegishi, T, Tomari, T, Nam, S-O, Aoki, M, Sueta, T, Nakagawa, T, Miyamoto, S, Nabeshima, K, Weaver, AM, and M. Seiki., “EphA2 proteolysis converts it from a tumor suppressor to an oncoprotein”, Cancer Research,<\/span> 75:3327-3339, 2015.PMCID: PMC4682662<\/a><\/p>\n

Hong, NH*, Qi, A, and Weaver, AM, “PI(3,5)P2 controls branched actin dynamics at late endosomes by regulating cortactin-actin interactions”, J. Cell Biology<\/span>, <\/em>210: 753-769, 2015. PMCID: PMC4555817<\/a>.<\/p>\n

Cha, DJ, Franklin, JL, Dou, Y, Liu Q, Higginbotham, JN, Beckler, MD, Weaver, AM, Vickers, K, Prasad, N, Levy, S, Zhang, B ,Coffey, RJ, and Patton, JG, “KRAS-dependent sorting of miRNA to exosomes”, eLife<\/span>, 2015. doi: 10.7554\/eLife.07197. PMCID: PMC4510696<\/a><\/p>\n

Sung BH, Ketova T, Hoshino D, Zjilstra A#, and Weaver, AM#, “Directional cell movement through tissues is controlled by exosome secretion.” Nature Communications<\/span>. 6:7164, 2015. #equal contribution and co-corresponding authors. PMCID:PMC4435734<\/a><\/p>\n

Young, CD, Zimmerman, LJ, Hoshino, D, Formisano, L, Hanker, AB, Gatza, ML, Morrison, MM, Moore, PD, Whitwell, CA, Dave, B, Stricker, T, Bhola, NE, Silva, GO, Patel, P, Brantley-Sieders, DM, Levin, M, Horiates, M, Palma, NA, Wang, K, Stephens, PJ, Perou, CM, Weaver, AM, O’Shaughnessy, JA, Chang, JC, Park, BH, Lieblder, DC, Cook, RS, Arteaga, CL. “Activating PIK3CA mutations induce an EGFR\/ERK paracrine signaling axis in basal-like breast cancer.” Molecular Cellular Proteomics<\/span>, 14:1959-1976, 2015. PMCID: PMC4587316<\/a><\/p>\n

French, CL, YE, F, Revetta, F, Zhang, B, Coffey, RJ, Washington, MK, Deane, NG, Beauchamp, RD, and Weaver, AM, “Linking patient outcome to high throughput protein expression data identifies regulators of colorectal adenocarcinoma aggressiveness”, F1000Research<\/span> 2015, 4:99 PMCID: PMC4457132<\/a><\/p>\n

Wirtz, ED, Hoshino, D, Maldonado, A, Tyson, DR, and Weaver, AM, “Response of Head and Neck Squamous Cell Carcinoma Cells Carrying PIK3CA Mutations to Selected Targeted Therapies”, JAMA Otolaryngol Head Neck Surg, <\/span>141:543-549, 2015. PMCID: PMC4474763<\/a><\/p>\n

Cleghorn, WM, Branch, KM, Kook, S, Arnette, C, Bulus, N, Zent R, Kaverina I, Gurevich, EV, Weaver, AM, Gurevich, VV. “Arrestins regulate cell spreading and motility via focal adhesion dynamics.” Molecular Biology of the Cell<\/span>. 26:622-635, 2015. PMCID: PMC4325834<\/a><\/p>\n

Riching, KM, Cox, BL, Salick, MR, Pehlke, C, Riching, AS, Ponik, SM, Mass, BR, Crone, WC, Jiang, Y, Weaver, AM, Eliceiri, KW, Keely, PJ. “3D collagen alignment limits protrusions to enhance breast cancer cell persistence.” Biophysical Journal,<\/span> 107:2546-2558, 2014. PMCID: PMC4255204<\/a><\/p>\n

Lee. B, Zhou, X, Riching, K, Eliceiri, KW, Keely PJ, Guelcher SA, Weaver, AM, Jiang, Y. “A three-dimensional computational model of collagen network mechanics.” PLOS One<\/span>, 9(11): e111896, 2014. PMCID: PMC4227658<\/a><\/p>\n

Ryzhov, S, Sung, BH, Zhang, Q, Weaver, AM, Gumina, RJ, Biagioni, I, And Feokstitov, I, “Role of adenosine A2B receptor signaling in contribution of cardiac mesenchymal stem-like cells to myocardial scar formation”, Purinergic Signaling, <\/span>10(3): 477-486, 2014. PMCID: PMC4152448<\/a><\/p>\n

Hoshino, D, Kirkbride, KC, Costello, K, Clark, ES, Sinha, S, Grega-Larson, N, Tyska, MJ, and Weaver, AM, “Exosome secretion is enhanced by invadopodia and drives invasive behavior”, Cell Reports<\/span>,\u00a0 5:1159-1168, 2013. PMCID:PMC3873329<\/a><\/p>\n

Benesh, EC, Miller, PM, Pfaltzgraff, ER, Grega-Larson, NE, Hager, HA, Sung, BH,\u00a0 Qu, X, Baldwin, HS, Weaver, AM# and Bader, DM#, “Bves and NDRG4 regulate directional cell migration through autocrine extracellular matrix deposition”, MBOC<\/span>, 24:3496-3510, 2013. # Co-corresponding authors. PMCID: PMC3826988<\/a><\/p>\n

Bryce, NS, Reynolds, AB, Koleske, AJ, and Weaver, AM, “WAVE2 regulates epithelial morphology and cadherin isoform switching”, PLOS One<\/span>, 8:e64533,2013. \u00a0PMCID: <\/span>PMC3654908<\/span><\/a>
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Hoshino, D, Jourquin, J, Emmons, SW, Miller, T, Goldgof, M, Costello, K, Tyson, DR, Brown, B, Lu, Y, Prasad, NK, Zhang, B, Mills, GB, Yarbrough, WG, Quaranta, V, Seiki, M, Weaver, AM, “Network Analysis of the Focal Adhesion to Invadopodia Transition Identifies a PI3K-PKCa Invasive Signaling Axis”, Science Signaling<\/span>, 5: 1-14, 2012.\u00a0PMCID: <\/span>PMC3583194<\/span><\/a><\/p>\n

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