Anna Wang Roe

 

 
 
 
 
 

“Reality is an illusion, albeit a persistent one.”

– Albert Einstein

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Feature Article: Optogenetics through windows on the brain

Optogenetics combines optics and genetics to control neuronal activity with cell-type specificity and millisecond temporal precision. So far, only a few studies have used optogenetics to modulate neuronal activity in the non-human primate. These studies have demonstrated proof of principle, but they have also highlighted the fact that existing methods of virus and light delivery in the...... KEEP READING

Posted on Monday, June 17th, 2013 in Feature Article | Comments Off


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Feature Article: Basis of BOLD Resting State Connectivity

Studies of resting state activity in the brain have provoked critical questions about the brain’s functional organization but, its biological basis is not clear. Specifically, the relationships between interregional correlations in resting state measures of activity, neuronal functional connectivity and anatomical connectivity are much debated. To investigate these relationships, we have examined both anatomical and...... KEEP READING

Posted on Wednesday, April 17th, 2013 in Feature Article | Tags: Comments Off


Unifying V4

Feature Article: Unifying V4

V4 is a mid-tier visual cortical area in the ventral visual pathway. Two bodies of literature emphasize V4’s role in visual object recognition and in visual attention. This review captures current knowledge of V4 and proposes a unifying view based on new-found functional organizations in V4.  It is proposed that the collection of functional domains...... KEEP READING

Posted on Tuesday, December 4th, 2012 in Feature Article | Tags: Comments Off


laminar

Feature Article: Identifying laminar cytoarchitecture via MR microscopy in awake monkeys

Brodmann divided the neocortex into 47 different cortical areas based on differences in laminar myeloarchitecture and cytoarchitecture. The ability to do so in vivo with anatomical magnetic resonance (MR) methods in awake subjects would be extremely advantageous. We used a combination of MR microscopy and new MR contrasts at 4.7 T with voxel size of...... KEEP READING

Posted on Tuesday, December 4th, 2012 in Feature Article | Tags: Comments Off


Motion Maps

Feature Article: Motion maps in Macaque V2

In mammals, the perception of motion starts with direction-selective neurons in the visual cortex. Despite numerous studies in monkey V1 and V2 (primary and second visual cortex), there has been no evidence of direction maps in these areas. In the present study, we used optical imaging methods to study the organization of motion response in...... KEEP READING

Posted on Tuesday, December 4th, 2012 in Feature Article | Comments Off


Function Image

Feature Article: Functional organization of V4

Visual area V4 in the macaque monkey contains a diverse complement of cells, including those with preference for color, orientation, disparity, as well as higher order feature preferences. However, unlike V1 and V2, it is unknown whether V4 is characterized by any distinct functional organizations. Here, using intrinsic signal optical imaging methods in awake, behaving...... KEEP READING

Posted on Tuesday, December 4th, 2012 in Feature Article | Comments Off


Featured Book Image

Feature Book: Imaging the Brain with Optical Methods

Imaging the Brain with Optical Methods presents the history of optical imaging and its use in the study of brain function, and the rapidly developing optical technologies and their applications that have recently developed. These include intrinsic signal optical imaging, near-infrared optical imaging, fast optical imaging based on scattered light, optical imaging with voltage sensitive...... KEEP READING

Posted on Tuesday, December 4th, 2012 in Featured Book | Comments Off


Rapid Spot Image

Feature Article: Rapid spot imaging method

In optical imaging experiments, it is often advantageous to map the field of view and to converge the eyes without electrophysiological recording. We have developed a rapid spot imaging method that can be conducted rapidly and repeatedly throughout an experiment. Using small 0.2° – 0.5° spots, we can quickly map 1) the extent of the...... KEEP READING

Posted on Tuesday, December 4th, 2012 in Feature Article | Comments Off


3D Maps

Feature Article: 3D Maps in Visual Area V2

When we open our eyes, the 3D visual world is projected onto the 2D plane of our retina. Our brain reconstructs the third dimension (depth) by comparing inputs from the two eyes. But where in the brain is this third dimension calculated? To answer this question, we have used a high spatial resolution brain imaging...... KEEP READING

Posted on Tuesday, December 4th, 2012 in Feature Article | Comments Off


Yin Yang Cover Image

Feature Article: Yin and Yang of color maps in the brain

Macaque monkey visual cortex (areas V1 and V2). Yin (right portion): optical image of V1 & V2 activation while monkey is viewing a color stimulus. Yang (left portion): cytochrome-oxidase (CO) stained brain slice of the imaged region. As shown in Lu and Roe 2008, color-activations in V1 (smaller patches) align with CO blobs in V1,...... KEEP READING

Posted on Tuesday, December 4th, 2012 in Feature Article | Comments Off


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Feature Article: Disparity Channels in Early Vision

Human beings and many other animals see the world with two eyes. However, each eye has a view which is slightly offset from the other. The brain has taken advantage of this offset, termed binocular disparity, to figure out distance and three dimensional depth information about the world, a capability called stereopsis. The last decade...... KEEP READING

Posted on Tuesday, December 4th, 2012 in Feature Article | Comments Off


vase

Feature Article: How our brain fills gaps

A vase from China’s Song dynasty demonstrates the use of very faint contrast borders to create the illusion of shading on a one-color background. The phenomenon is known as edge induction. The image of the vase is overlaid over the Cornsweet illusion, in which the left half of a rectangle divided in two looks lighter...... KEEP READING

Posted on Tuesday, December 4th, 2012 in Feature Article | Comments Off


Power of Proximity

Feature Article: The Power of Proximity

In Michelangelo’s Creation of Adam (Sistine Chapel), God stretches out His right index to the first man. In a return gesture, Adam mirrors the movement, reaching out his own hand to meet the Creator’s animating spark. Graphs on either side illustrate activations in somatosensory cortex in response to real and illusory digit tip stimulation.* Chen...... KEEP READING

Posted on Tuesday, December 4th, 2012 in Feature Article | Comments Off