Publications
Preprints under review
25. C.K. Rohler, K.A. Hess, L.E. Buchanan. “Advances in probing amyloid heterogeneity using vibrational spectroscopy and imaging” Invited perspective, Journal of Physical Chemistry B.
24. R.F. Capone*, J.M. Hutchison*, A.L. Cao, G. Li, J.B. Hayes, M. Goodman, M. Castro, W.B. Weeks, S. Vaithiyalingam, Q. Zhou, C.R. Sanders, L.E. Buchanan. “Water Soluble Integral Membrane Protein Nanoparticles,” doi:10.26434/chemrxiv-2025-nkgp3. *denotes equal co-first authors
Publications while at Vanderbilt University
23. A.L. Cao, L.M. Weissman, L.E. Buchanan. “Transition Dipole Strength as a Quantitative Tool for Protein Secondary Structure Analysis.” Journal of Physical Chemistry B, 129, 8382 (2025). doi: 10.1021/acs.jpcb.5c04203
22. D.R. Boutwell, A.L. Cao, A. Walker, L.E. Buchanan. “Machine Learning-Based Approaches to Improving Transition Dipole Strength Calculations.” Journal of Physical Chemistry B, 129, 8360 (2025). doi: 10.1021/acs.jpcb.5c03566
21. A. Antevska*, K.A. Hess*, C.C. Long, J. Jang, K.L. Cantrell, L.E. Buchanan, T.D. Do. “Deciphering the Molecular Dance: Exploring the Dynamic Interplay between Mouse Insulin B9-23 Peptides and Their Mutants,” Biochemistry, 63, 2245-2256 (2024). DOI: 10.1021/acs.biochem.4c00217 *denotes equal co-first authors
20. Kayla A. Hess, Cade K. Rohler, Dalton R. Boutwell, Jason M. Snyder, Lauren E. Buchanan. “Suppressing sidechain modes and improving structural resolution for 2D IR spectroscopy via vibrational lifetimes,” Journal of Chemical Physics, 161, 054201 (2024). DOI: 10.1063/5.0207523
19. K.R. Webb*, K.A. Hess*, A. Shmidt†, K.D Segner†, L.E. Buchanan. “Probing local changes to α-helical structures with 2D IR spectroscopy and isotope labeling,” Biophysical Journal, 122, 1491-1502 (2023). DOI: 10.1016/j.bpj.2023.03.014 *denotes equal co-first authors; †denotes undergraduate coauthor
18. , “Determining the impact of gold nanoparticles on amyloid aggregation with 2D IR spectroscopy”, Journal of Chemical Physics 158, 091101 (2023) DOI: 10.1063/5.0136376 †denotes undergraduate coauthor
17. W.B. Weeks, L.E. Buchanan. “Label-free detection of β-sheet polymorphism,” Journal of Physical Chemistry Letters, 13, 9534-9538 (2022). DOI: 10.1021/acs.jpclett.2c02292
16. R.E. Wilkinson, K.N. Kraichely, C.M. Hendy, L.E. Buchanan, S. Parnham, M.W. Giuliano. “The neuropeptide galanin adopts an irregular secondary structure,” Biochemical and Biophysical Research Communications, 626, 121-128 (2022). DOI: 10.1016/j.bbrc.2022.08.032 †denotes undergraduate coauthor
15. Weeks WB, Tainter CJ, Buchanan LE, “Investigating the effects of N-terminal acetylation on KFE8 self-assembly with 2D IR spectroscopy,” Biophysical Journal, 121, 1549-1559 (2022). DOI: 0.1016/j.bpj.2022.03.003
14. L.E. Buchanan, W. Xiong. “Two-dimensional Infrared (2D IR) Spectroscopy.” In: R. Guenther and D. Steel, ed., Encyclopedia of Modern Optics II, 2nd ed. Oxford: Elsevier, pp 164-183 (2018). DOI: 10.1016/B978-0-12-803581-8.09527-8
13. L.E. Buchanan, M. Maj, E.B. Dunkelberger, P.-N. Cheng, J.S. Nowick, M.T. Zanni. “Amyloid polymorphs reveal competing pathways for the formation of hIAPP fibrils and help identify the transition state,” Biochemistry, 57, 6470-6478 (2018). DOI: 10.1021/acs.biochem.8b00997
Publications prior to Vanderbilt University
12. L.E. Buchanan, M.O. McAnally, N.L. Gruenke, G.C. Schatz, R.P. Van Duyne. “Studying stimulated Raman activity in surface-enhanced femtosecond stimulated Raman spectroscopy by varying the excitation wavelength,” Journal of Physical Chemistry Letters, 8, 3328-3333 (2017).
11. L.E. Buchanan, N.L. Gruenke, M.O. McAnally, B. Negru, H.E. Mayhew, V.A. Apkarian, G.C. Schatz, R.P. Van Duyne. “Surface-enhanced femtosecond stimulated Raman spectroscopy 1 MHz repetition rates,” Journal of Physical Chemistry Letters, 7, 4629-4634 (2016).
10. A.W. Parker, T.O. Zhang, L.E. Buchanan, M.T. Zanni. “Insights into amylin aggregation by 2D IR spectroscopy,” Biomedical Spectroscopy and Imaging, 3, 189-96 (2014).
9. L.E. Buchanan, J.K. Carr, A.M Fluitt, A.J. Hoganson, S.D. Moran, J.J. de Pablo, J.L. Skinner, M.T. Zanni. “Structural motif of polyglutamine amyloid fibrils discerned with mixed-isotope infrared spectroscopy,” Proceedings of the National Academy of Sciences, 111, 5796-5801 (2014).
8. L.E. Buchanan, E.B. Dunkelberger, H.Q. Tran, P.-N. Cheng, C.-C. Chiu, P. Cao, D.P. Raleigh, J.J. dePablo , J.S. Nowick, M.T. Zanni, “Mechanism of IAPP amyloid fibril formation involves an intermediate with a transient β-sheet,” Proceedings of the National Academy of Sciences, 110, 19285-90 (2013). *Highlighted in “Unfolding Diabetes,” Chemical & Engineering News, 91 (46), 5 (2013).
7. L. Wang, L.E. Buchanan, E.B. Dunkelberger, J.J. de Pablo, M.T. Zanni, J.L. Skinner, “Ultrafast Infrared Spectroscopy of Amylin Solution and Fibrils,” in Ultrafast Infrared Vibrational Spectroscopy, M.D. Fayer, Ed. CRC Press: Boca Raton, 437-460 (2013).
6. J. Carr, L.E. Buchanan, M.T. Zanni, J.L. Skinner, “Structure and dynamics of urea/water mixtures investigated by vibrational spectroscopy and molecular dynamics simulation,” Journal of Physical Chemistry B, 117, 13291-300, (2013).
5. E.B. Dunkelberger, L.E. Buchanan, P. Marek, P. Cao, D.P. Raleigh, M.T. Zanni, “Deamidation accelerates amyloid formation and alters amylin fiber structure,” Journal of the American Chemical Society, 134, 12658-67 (2012). *Highlighted in “Spectroscopic Technique Spots Effects of Deamidation on Proteins”, Chemical & Engineering News, [online] July 6, 2012.
4. S.D. Moran, A.M. Woys, L.E. Buchanan, E. Bixby, S.M. Decatur, M.T. Zanni, “Two-dimensional IR spectroscopy and segmental 13C labeling reveals the domain structure of human γD-crystallin amyloid fibrils,” Proceedings of the National Academy of Sciences, 109, 3329-34 (2012). *Highlighted in “Domain Structure of Cataract Amyloids,” Chemical & Engineering News, 90 (7), 37 (2012).
3. L.E. Buchanan, E.B. Dunkelberger, M.T. Zanni, “Examining amyloid structure and kinetics with 1D and 2D infrared spectroscopy and isotope labeling,” in Protein Folding and Misfolding, H. Fabian and D. Nauman, Eds. Springer: Heidelberg, 217-237 (2011).
2. C.T. Middleton, L.E. Buchanan, E.B. Dunkelberger, M.T. Zanni, “Utilizing lifetimes to suppress random coil features in 2D IR spectra of peptides,” Journal of Physical Chemistry Letters, 2, 2357-2361 (2011).
1. A.S. Reddy, L. Wang, S. Singh, Y.L. Ling, L. Buchanan, M.T. Zanni, J.L. Skinner, J.J. de Pablo, “Stable and metastable states of human amylin in solution,” Biophysical Journal, 99, 2208-16 (2010).
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