M Wt. 266
Formula: C₁₆ H₁₄ N₂ S
Smiles:

Phenotype

Descriptor

Anatomical Features AR1299

Axis	Reduced length
Blood	Present
Blood circulation	Absent, pooling
Brain	Abnormal
Cloaca	Absent
Eye	Reduced size
Eye pigmentation	Reduced amount
Forebrain	Reduced size
Fourth ventricle	Normal
Head	Reduced size
Heart	Abnormal, reduced size
Heart contraction	Abnormal
Locomotion	Reduced amount
Melanocyte	Reduced amount
Midbrain hindbrain boundary	Present
Notochord	Reduced width, reduced length
Otic placode	Reduced size
Otolith	Normal
Pericardium	Swollen
Post-vent region	Absent
Somite	Abnormal
Third Ventricle	Reduced size
Trunk	Reduced length
Tail	Absent
Whole organism	Reduced length
Yolk	Increased size

Cheminformatics

Molinspiration

Bioactivity score v2016.03
GPCR ligand                     -0.14
Ion channel modulator      -0.06
Kinase inhibitor                  0.11
Nuclear receptor ligand    -0.22
Protease inhibitor             -0.31
Enzyme inhibitor               0.05

ChemProt TC>0.97

N/A

Lasso

Category	Target	PDB Code	LASSO Score
Kinases	P38 MAP, P38 mitogen activated protein	1kv2	0.94
Kinases	VEGFr2, vascular endothelial growth factor receptor	1vr2	0.85
Kinases	PDGFrb, platelet derived growth factor receptor kinase	N/A	0.71

Confirmed Pathway Activity

Synergist

Wnt signaling (EC2X): Does not potentiate

Confirmed Targets

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