M.Wt: 302.8
Formula: C₁₇H₁₅ClO₃
Smiles: COC1=CC=C(/C(C=O)=C(Cl)\C2=CC=C(OC)C=C2)C=C1

Phenotype

 

 

SwissADME

 

Confirmed Pathway Activity

Antagonist

Wnt signaling (IC50): 1.5 uM

Confirmed Targets

P300 (IC₅₀ = 4.2 uM) *using racemic mixture with 13% Z-isomer

 

Additional Information

Publications

Hao J, Ao A, Zhou L, Murphy CK, Frist AY, Keel JJ, Thorne CA, Kim K, Lee E, Hong CC. Selective small molecule targeting β-catenin function discovered by in vivo chemical genetic screen. Cell reports. 2013 Sep 12;4(5). 898-904.

Citations: 32 (May 2017)

 

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