Program and Time Schedule

Overview
Biological clocks are the endogenous oscillators that coordinate physiological and behavioral rhythms in nearly all organisms. This course examines how these rhythms are generated and regulated at the molecular, cellular and systems levels. We will cover the relevance of biological timing to the ecology and health of everything from protozoans to plants to people.
Objectives
Students in the Chronobiology Summer School should have four major objectives: 1) to learn about the molecules, cells, and systems of biological timing systems, 2) to master reading scientific literature with a critical eye and 3) to execute and interpret an experiment on human biological rhythms and 4) to contribute to public understanding of biological timing.
Course
materials
:
All readings, slides from lectures and assignments will be provided.
Readings: You will be asked to read book
chapters, review articles and the primary literature.
Problem sets:
These short assignments challenge you to apply quantitative analyses and
modeling to understand the basis for biological timing.
Experiment: You will collect data on your own biological rhythms.
Meet the Instructors:
  • Colleen Doherty, Ph.D. Center for
    Chronobiology and Cell and Developmental Biology, University of
    California, San Diego
  • Karen Gamble, Ph.D.
    University of Alabama, Birmingham
  • Shubhroz Gill, Ph.D.
    Center for Chronobiology and Division of Biological Sciences, University of
    California, San Diego
  • Erik Herzog, Ph.D.
    Departments of Biology, Anatomy and Neurobiology, Washington
    University
  • Carl Johnson, Ph.D. Department of
    Biological Sciences, Vanderbilt University
  • Dominic Landgraf, Ph.D. Center for
    Chronobiology and Department of Psychiatry, University of
    California, San Diego
  • Doug McMahon, Ph.D. Department of
    Biological Sciences, Vanderbilt
    University
  • Terry Page, Ph.D.
    Department of Biological Sciences, Vanderbilt University
  • Till Roenneberg, Ph.D. Institute of Medical
    Physiology, Ludwig-Maximillans, University, Munich, Germany
  • William Schwartz, M.D., Department of Neurology, University of
    Massachusetts Medical School

SCHEDULE

Day 1, Sunday, July 21, 2013
11 a.m. – 4:00 p.m.          Check-In – Murray House at the Commons (1501 18th Avenue South)
4:00 p.m. – 4:30 p.m.       Welcome (Herzog and McMahon) – 1220 Medical Research Building III
4:30 p.m. – 5:30 p.m.        Factor X: The history and concepts of chronobiology (Schwartz) – 1220 Medical Research Building III
5:30 p.m. – 6:30 p.m.       Dinner – Commons Center (Please be in the dining hall promptly at 5:40 p.m.)
7:00 p.m.,                         Initiation of class experiment on human circadian rhythms (Herzog) – 1220 Medical Research Building III
Day 2, Monday, July 22, 2013
7:45 a.m.,                         Breakfast – Commons Center (Please be in the dining hall promptly at 7:45 a.m.)
9:00 a.m. – 10:00 a.m.     Ecology of circadian clocks: Chronotypes and adaptive value (Roenneberg) – 2212 Stevenson Center
10:00 a.m. – 11:00 a.m.    Setting phase: Pittendrigh, Daan and Aschoff (Page) – 2212 Stevenson Center
11:00 a.m. – 12:00 p.m.   Limitations of prior entrainment models & new perspectives (Roenneberg) – 2212 Stevenson Center
12:00 p.m. – 2:00 p.m.     Lunch – Commons Center (Please be in the dining hall promptly at 12:15 p.m.)
2:00 p.m. – 3:00 p.m.       Photoentrainment pathways I: Cells (McMahon) – 1220 Medical Research Building III
3:00 p.m. – 3:15 p.m.        Demo of chemical oscillating reaction (Spears) – 4309 Stevenson Center
3:15 p.m. – 4:00 p.m.        Photoentrainment pathways II: Molecules (McMahon) – 1220 Medical Research Building III
4:00 p.m. – 5:00 p.m.       Break-Out Groups: Entrainment problems (Locations will be announced)
5:00 p.m. – 5:30 p.m.       Discussion: Entrainment problems – 1220 Medical Research Building III
5:30 p.m. – 7:00 p.m.       Dinner – Commons Center (Please be in the dining hall promptly at 5:40 p.m.)
7:00 p.m. – 7:30 p.m.      Datablitz – 1220 Medical Research Building III
8:00 p.m.                           Student Poster Session – Medical Research Building III Lobby
Day 3, Tuesday, July 23, 2013
7:45 a.m.                         Breakfast – Commons Center (Please be in the dining hall promptly at 7:45 a.m.)
9:00 a.m. – 10:00 a.m.    Molecular basis of circadian rhythm generation I: TTFL (McMahon) – 2212 Stevenson Center
10:00 a.m. – 11:00 a.m.  Break-Out Groups: Hot Topics (Locations will be announced)
11:00 a.m. – 12:00 p.m., Molecular basis of circadian rhythm generation II: New Perspectives (Johnson) – 2212 Stevenson Center
12:00 p.m. – 2:00 p.m.    Lunch – Commons Center (Please be in the dining hall promptly at 12:15 p.m.)
2:00 p.m. – 3:00 p.m.     The suprachiasmatic nucleus: A master circadian pacemaker (Schwartz) – 1220 Medical Research Building III
3:00 p.m. – 4:00 p.m.      A clock shop: Multi-oscillator systems, jetlag and limit cycle oscillators (Page) – 1220 Medical Research Building III
4:00 p.m. – 4:15 p.m.       Demo of molecular models of circadian rhythms (Herzog) – 1220 Medical Research Building III
4:15 p.m. – 4:30 p.m., Break
4:30 p.m. – 5:30 p.m.      Break-Out Groups: Molecular clocks problems (Locations will be announced)
5:30 p.m. – 7:00 p.m.      Dinner – Commons Center (Please be in the dining hall promptly at 5:40 p.m.)
7:00 p.m. – 8:00 p.m.      Discussion: Mutations and chronotypes (Roenneberg) – 1220 Medical Research Building III
8:00 p.m.                         Student Poster Session – Medical Research Building III Lobby
Day 4, Wednesday, July 24, 2013
7:45 a.m.                         Breakfast – Commons Center (Please be in the dining hall promptly at 7:45 a.m.)
9:00 a.m. – 10:00 a.m.    Synchronizing circadian clocks to each other (Herzog) – 2212 Stevenson Center
10:00 a.m. – 11:00 a.m.   Clocks & Metabolism (Johnson & Gill) – 2212 Stevenson Center
11:30 a.m. – 6:00 p.m.    Daytrip to Mammoth Cave (Board bus in the circular drive outside of Medical Research Building III. Remember to wear your sneakers. Please pick up your box lunches and bottled water on the way to the bus.)
1:30 p.m.                        Approximate Arrival at Mammoth Cave
2:00 – 3:00 p.m.              Public Lecture by Bill Schwartz – Mammoth Cave Training Center
3:00 – 5:00 p.m.              Cave Tour
7:00 p.m.                        Free Evening & Dinner on Your Own – Enjoy Music City
Day 5, Thursday, July 25, 2013
7:45 a.m.                                Breakfast – Commons Center (Please be in the dining hall promptly at 7:45 a.m.)
9:00 a.m. – 10:00 a.m.         Clock control of excitability (Gamble) – 2212 Stevenson Center
10:00 a.m. – 11:00 a.m.       Photoperiodism (Doherty & Landgraf) – 2212 Stevenson Center
11:00 a.m. – 12:00               Break-Out Groups: Hot topics (Locations will be announced)
12:00 p.m. – 2:00 p.m.         Lunch – Commons Center (Please be in the dining hall promptly at 12:15 p.m.)
2:00 p.m. – 3:00 p.m.           Evolution of clocks: Past, present and future (Johnson) – 1220 Medical Research Building III
3:00 p.m. – 3:15 p.m.           Break
3:15 p.m. – 4:30 p.m.           Circadian disorders (Schwartz) – 1220 Medical Research Building III
4:30 p.m. – 5:30 p.m.           Break-Out Groups: Chronotherapy (Locations will be announced)
5:30 p.m. – 7:00 p.m.           Dinner – Commons Center (Please be in the dining hall promptly at 5:40 p.m.)
7:00 p.m. – 8:00 p.m.           Discussion – 1220 Medical Research Building III
8:00 p.m.                                Student Poster Session – Medical Research Building Lobby
9:00 p.m.                                Closing Remarks (McMahon and Herzog) – 1220 Medical Research Building III

Day 6, Friday, July 26, 2013

7:45 a.m.                                Breakfast – Commons Center (Please be in the dining hall promptly at 7:45 a.m.)
9:00 a.m. – 12:00 p.m.         Check-Out
Break-Out Group
6 groups of ~5 Students Each
Afternoon sessions: students will work as a team to solve “problems in chronobiology” (e.g. design experiments to test hypotheses, evaluate strengths and weaknesses of specific techniques, critique a recent or classic paper, recognize ambiguous terms, etc.). Prior readings could be assigned.

  • Modeling circadian clocks
  • Development of the circadian system
  • Aging of the circadian system
  • Metabolism and clocks (Shubhroz Gill)
  • Clock manipulations in single celled organisms
  • Clock manipulations in arthropods
  • Clock manipulations in mammals (Dominic Landgraf)
  • Clock manipulations in plants (Colleen Doherty)
  • Studying clocks in people
  • Analysis of rhythmic data (Gamble)

Important Miscellaneous Information

Airport Transportation – If you are flying into Nashville International Airport (BNA), you may hail a taxi outside of baggage claim. The address you will need to give the driver is 1501 18thAvenue South. Your check-in and lodging will be at the Murray House on the Vanderbilt Campus. For your return flight, you will need to call a taxi service and make arrangements for pick-up. We recommend Yellow Cab (615-256-0101), Nashville Cab (615-333-3333), or Checkered Cab (615-256-7000). Please be sure to plan to arrive at the airport at least two hours prior to your flight.
Weather & Packing – The Nashville July average daily temperatures are highs of 90°F and lows of 70°F. Nashville is very hot and humid in July so please plan appropriately. You may want a light jacket or sweater for the Mammoth Cave trip and you will need sneakers as well.
Meals – Most of your meals will be in the Commons Center Dining Hall. You will be given a meal ticket when you check-in. Please present this when going through the dining hall meal line. The only meals not served in the dining hall will be lunch and dinner on Wednesday, July 24th. You will be given a box lunch for the field trip to Mammoth Cave. Dinner on Wednesday, July 24th will be on your own giving you time to explore Music City. Restaurant suggestions will be given to you at check-in.
WiFi – WiFi will be available in both your lodging and class rooms. Instructions will be given to you at check-in.
Suzie’s Coffee Shop – Located on the 3rd floor of the Medical Research Building III, Suzie’s offers an assortment of delicious sandwiches, bagels, muffins, wraps, coffee, soft drinks and many other treats. Suzie’s takes cash, Visa, and Mastercard.
Commons Center Exercise Room – The Commons Center exercise room offers a convenient place for both cardiovascular and anaerobic exercise. Hours for the facility are:
    July 21 – 8:00 a.m.- 7:00 p.m.
    July 22 – 7:00 a.m. – 7:00 p.m.
    July 23 – 7:00 a.m. – 7:00 p.m.
    July 24 – 7:00 a.m. – 7:00 p.m.
    July 25 – 7:00 a.m. – 7:00 p.m.
    July 26 – 7:00 a.m. – 5:00 p.m.