David Samuels’ peer-reviewed publications on mitochondrial DNA evolution

Links to full text are in the journal titles

 

Global human frequencies of predicted nuclear pathogenic variants and the role played by protein hydrophobicity in pathogenicity potential

Luisa Periera, Pedro Soares, Petr Triska, Teresa Rito, Agnes van der Waerden, Biao Li, Predrag Radivojac, David C Samuels (2014), Scientific Reports. 4:7155

 

Evaluating Purifying Selection in the Mitochondrial DNA of Various Mammalian Species

Pedro Soares, Diogo Abrantes, Teresa Rito, Noel Thomson, Predrag Radivojac, Biao Li, Vincent Macauley, David C. Samuels, Luisa Pereira (2013), PLoS One, 8 (3), e58993 PMC3606437

 

Comparing phylogeny and the predicted pathogenicity of protein variations reveals equal purifying selection across the global human mtDNA diversity

L. Pereira, P. Soares, P. Radivojac, B. Li, D.C. Samuels (2011), American Journal of Human Genetics 88, 433-439. PMC3071914

The diversity present in 5140 human mitochondrial genomes

L. Pereira, F. Freitas, V. Fernandes, J.B. Pereira, M.D. Costa, S. Costa, V. Maximo, V. Macaulay, R. Rocha, D.C. Samuels (2009) American Journal of Human Genetics 84 (5) 628-640. PMC2681004.

 

The mitochondrial genome sequence and molecular phylogeny of the turkey, Meleagris gallopavo

X. Guan, P. Silva, O. Ho-Shing, K.B. Gyenai, J. Xu, T. Geng, Z. Tu, D.C. Samuels, O.E. Rhodes, E.J. Smith (2009), Animal Genetics 40(2): 134-141. PMC2664387.

 

Evidence for variable selection pressures at a large secondary structure of the human mitochondrial DNA control region

F. Pereira, P. Soares, J. Carneiro, L. Pereira, M.B. Richards, D.C. Samuels, A. Amorim, (2008), Molecular Biology and Evolution 25(12): 2759-2770. PMID:18845547.

 

Pathogenic mitochondrial DNA mutations are common in the general public

H.R. Elliot, D.C. Samuels, J.A. Eden, C.L. Relton, P.F. Chinnery (2008). American Journal of Human Genetics 83: 254-260. PMC2495064.

 

Is selection required for the accumulation of somatic mitochondrial DNA mutations in post-mitotic cells?

S.E. Durham, D.C. Samuels, P.F. Chinnery (2006) Neuromuscular Disorders 16 (6): 381-386. PMID:16684599.

 

Mitochondrial-encoded membrane protein transcripts are pyrimidine-rich while soluble protein transcripts and ribosomal RNA are purine-rich

P.C. Bradshaw, A. Rathi, D.C. Samuels (2005), BMC Genomics 6: Art. No. 136. PMC1262711.

 

Life span is related to the free energy of mitochondrial DNA

D.C. Samuels (2005), Mechanisms of Ageing and Development 126 (10): 1123-1129. PMID:15992863.

 

Mitochondrial DNA repeats constrain the life span of mammals

D.C. Samuels (2004), Trends in Genetics 20 (5): 226-229. PMID:15109774.

 

A compositional segmentation of the human mitochondrial genome is related to heterogeneities in the guanine mutation rate

D.C. Samuels, R.J. Boys, D.A. Henderson, P.F. Chinnery (2003), Nucleic Acids Research 31 (20): 6043-6052. PMC219467.