David Samuels’ peer-reviewed publications on mitochondrial DNA replication

Links to full text are in the journal names

 

Recurrent tissue-specific mtDNA mutations are common in humans

David C. Samuels, Chun Li, Bingshan Li, Zhuo Song, Eric Torstenson, Hayley Boyd Clay, Antonis Rokas, Tricia A Thortnon-Wells, Jason H. Moore, Tia M. Hughes, Robert D. Hoffman, Jonathan L. Haines, Deborah G. Murdock, Douglas P. Mortlock, Scott M. Williams (2013) PLoS Genetics 9(11) e1003929 PMC3820769.

 

Non-random mtDNA segregation patterns indicate a metastable heteroplasmic segregation unit in m.3243A>G cybrid cells

Anton K. Raap, Roshan S. Jahangor Tafrechi, Frans M. van de Rijke, Angela Pule, Carolina Wahlby, Karoly Szuhai, Raimond B.G. Ravelli, Rene F.M. de Coo, Harsha K. Rajasinha, Mats Nilsson, Patrick F. Chinnery, David C. Samuels and George M.C. Janssen (2012), PLoS One 7(12) e52080 PMC3525564

 

Variation in germline mtDNA heteroplasmy is determined prenatally but modified during subsequent transmission

Christoph Freyer, Lynsey M Cree, Arnoud Mourier, James B Stewart, Camilla Koolmeister, Dusanka Milenkovac, David C Samuels, Nils-Goran Larsson, Patrick F Chinnery (2012), Nature Genetics (44) 1282-1285. PMC3492742

 

Correlated Tissue Expression of Genes of Cytoplasmic and Mitochondrial Nucleotide Metabolisms in Normal Tissues is Disrupted in Transformed Tissues

V.V. Gandhi, D.C. Samuels (2012), Nucleosides, Nucleotides and Nucleic Acids 31, 112-129. PMC3464496

 

Replication Pauses of the Wild-Type and Mutant Mitochondrial DNA Polymerase Gamma: A Simulation Study

Z. Song, Y. Cao, D.C. Samuels (2011), PLoS Computational Biology 7(11), e1002287.

 

Enzyme kinetics of the mitochondrial deoxyribonucleoside salvage pathway are not sufficient to support rapid mtDNA replication

V.V. Gandhi, D.C. Samuels (2011), PLoS Computational Biology 7(8), e1002078. PMC3150320

 

A review comparing deoxyribonucleoside triphosphate (dNTP) concentrations in the mitochondrial and cytoplasmic compartments of normal and transformed cells

V.V. Gandhi, D.C. Samuels (2011) Nucleosides, Nucleotides and Nucleic Acids 30(5), 317-339. PMC3210641

 

Mitochondrial aging is accelerated by anti-retroviral therapy through clonal expansion of mtDNA mutations

B.A.I. Payne, I.J. Wilson. C.A. Hateley, R. Horvath, M. Santibanez-Koref, D.C. Samuels, D.A. Price, P.F. Chinnery (2011), Nature Genetics 43 (8), 806-810. PMC3223397

 

POLG mutations cause decreased mitochondrial DNA repopulation rates following induced depletion in human fibroblasts

J.D. Stewart, S, Schoeler, K.S. Sitarz, R. Horvath, K. Hallmann, A. Pyle, P. Yu-Wai-Man, R.W. Taylor, D.C. Samuels, W.S. Kunz, P.F. Chinnery (2011), Biochemica et Biophysica Acta 1812, 321-325. PMID:21138766.

 

Analysis of enzyme kinetic data for mtDNA replication

Z. Song, D.C. Samuels, (2010), Methods 51(4), 385-391. PMC2903644

 

An Analysis of Enzyme Kinetics Data for Mitochondrial DNA Strand Termination by Nucleoside Reverse Transcriptase Inhibitors

K.V. Wendelsdorf, Z. Song, Y. Cao, D.C. Samuels (2009), PLOS Computational Biology 5(1) e1000261. PMC2603287.

 

The evidence that the DNC (SLC25A19) is not the mitochondrial deoxyribonucleotide carrier

J. Kang and D.C. Samuels (2008), Mitochondrion 8: 103-108.PMID:18280798.

 

Selection against pathogenic mtDNA mutations in a stem cell population leads to the loss of the 3243A>G mutation in blood

H.K. Rajasimha, P.F. Chinnery, D.C. Samuels (2008), American Journal of Human Genetics 82: 333-343. PMC2427290.

 

Depletion of mitochondrial DNA in leucocytes harbouring the 3243A -> G mtDNA mutation

A. Pyle, R.W. Taylor, S.E. Durham, M. Deschauer, A.M. Schaefer, D.C. Samuels, P.F. Chinnery (2007), Journal of Medical Genetics 44 (1): 69-74. PMC2597915.

 

A model of the nuclear control of mitochondrial DNA replication,

G.J. Capps, D.C. Samuels, P.F. Chinnery (2003) Journal of Theoretical Biology 221 (4): 565-583. PMID:12713941.

 

Mitochondrial DNA mutations accumulate in ageing, cancer and mitochondrial disease: Is there a common mechanism?

P.F. Chinnery, D.C. Samuels, J.L. Elson, D.M. Turnbull (2002) Lancet 360 (9342): 1323-1325. PMID:12414225.

 

Random intracellular drift explains the clonal expansion of mitochondrial DNA mutations with age

J.L. Elson, D.C. Samuels, D.M. Turnbull, P.F. Chinnery (2001), American Journal of Human Genetics 68: 802-806. PMC1274494.

 

Random genetic drift determines the level of mutant mitochondrial DNA in human primary oocytes

D.T. Brown, D.C. Samuels, E.M. Michael, D.M. Turnbull, P.F. Chinnery (2001), American Journal of Human Genetics 68: 533-536. PMC1235288.

 

The inheritance of mitochondrial DNA heteroplasmy: random drift, selection or both?

P.F. Chinnery, D.R. Thorburn, D.C. Samuels, S.L. White, H.H.M. Dahl, D.M. Turnbull, R.N. Lightowlers, N. Howell (2000) Trends in Genetics 16: 500-505. PMID:11074292.

 

Relaxed replication of mtDNA: A model with implications for the expression of disease

P.F. Chinnery, D.C. Samuels (1999), American Journal of Human Genetics 64: 1158-1165. PMC1377840.