The Sebzda lab studies lymphocyte (B, T, and NK cell) trafficking during immune responses.
Specifically, we are interested in how cell activation releases these lymphocytes from homeostatic migration patterns and targets these cells to sites of inflammation. We are currently using a series of genetically modified animal models to analyze early regulatory events in cellular trafficking.
The ultimate goal of this research is to identify potential therapeutic targets that enhance/inhibit lymphocyte trafficking to specific tissues and thus aid in pathogen clearance or limit autoimmune reactions, respectively.
Read more about our work in the VUMC Reporter:
- A closer look into the immune system’s playbook
- Factor’s role in distributing immune cells discovered
- Regulating immune regulators