{"id":7,"date":"2012-11-12T20:03:37","date_gmt":"2012-11-12T20:03:37","guid":{"rendered":"https:\/\/my.vanderbilt.edu\/guengerichlab\/current-courses\/"},"modified":"2026-01-06T16:29:20","modified_gmt":"2026-01-06T21:29:20","slug":"current-courses","status":"publish","type":"page","link":"https:\/\/my.vanderbilt.edu\/guengerichlab\/current-courses\/","title":{"rendered":"References and Articles"},"content":{"rendered":"<p style=\"text-align: justify\"><strong>Recent Articles<\/strong><\/p>\n<ul style=\"text-align: justify\">\n<li>Zhu, Z., Chung, Y.-M., Alyamani, M., Dai, Y., McCarty, K.D., Roberts, E., Sinha, S., Li, J., Li, X., Gad, E.M., Zhou, C., Shi, J., Burgess, R.A., Hargrove, T.Y., Lepesheva, G.I., Guengerich, F.P., Auchus, R.J., and Sharifi, N. (2025)<i>\u00a0Nature Commun.16<\/i>, 10611.<i><\/i>\u201cA Bypass Gateway from Cholesterol to Sex Steroid Biosynthesis.\u201d<\/li>\n<li>Elizondo, A.I., McCarty, K.D., Guengerich, F.P., Arman, HJ.D., and Yoshimoto, F.K. (2025)\u00a0<i>Org. Biomolec. Chem. 23\u00a0<\/i>(42) 9457-9724. \u201cA Synthesis of 1b-Hydroxytestosterone, a Metabolite of Xenobiotic Human Cytochrome P450 Enzymes, Beginning with a Borylation of Boldione.\u201d (selected for cover art)<\/li>\n<li>McCarty, K.D., Tateishi, Y., and Guengerich, F.P. (2025)\u00a0<i>J. Biol. Chem. 301<\/i>, 110378. \u201cCytochrome P450<sub>BM-3\u00a0<\/sub>and P450 11A1 Retain Compound I (FeO<sup>3+<\/sup>) Chemistry with Electrophilic Substrates Poised for Compound 0 (Fe<sup>3+<\/sup>O<sub>2<\/sub>\u00af) Reactions.\u201d<\/li>\n<li>McCarty, K.D., and Guengerich, F.P. (2025)\u00a0<i>J. Am. Soc. Mass Spectrom. 36<\/i>, 1702-1717.<i>\u00a0<\/i>\u00a0\u201cMass Spectral Analysis of Sterols and Other Steroids in Different Ionization Modes: Sensitivity and Oxidation Artifacts.\u201d<\/li>\n<li>Hong, J.-K., Yeom, M., Hwang, H.-Y., Mun, E., Woo, J.-H., Kim, Y., Shin, J.-H. Lee, Y., Kim, D., Guengerich. F.P., and Choi, J.-Y. (2025) <i style=\"font-family: inherit;font-size: 16.0016px\">Chem.-Biol. Interact.<\/i><i>416<\/i>, 111551<i style=\"font-family: inherit;font-size: 16.0016px\">. <\/i>\u201cFour Germline\u00a0POLH\u00a0Variants, Including Two Found in Skin Tumors, Impair DNA Polymerase\u00a0h\u00a0Function and Cellular Tolerance to UV Radiation and Cisplatin.\u201d<\/li>\n<li>McCarty, K.D., and Guengerich, F.P. (2025) <i style=\"font-family: inherit;font-size: 16.0016px\">J. Biol. Chem. 301<\/i>, 108168. \u201cLiver Fatty Acid Binding Protein FABP1 Transfers Substrates to Cytochrome P450 4A11 for Catalysis.\u201d<\/li>\n<li>Koinuma, K., Noto, K., Morita, T., Uekusa, Y., Kikuchi, H., Shimoji,\u00a0 M., Seki, H., Yamazaki, H., Guengerich, F. P., Nakamura, K., Yamamoto, K., Imaoka, A., Akiyoshi, T., and Ohtani, H. (2025) <i style=\"font-family: inherit;font-size: 16.0016px\">J. Pharmaceut. Sci<\/i>. <i style=\"font-family: inherit;font-size: 16.0016px\">114<\/i>, 849-856. \u201cKinetics of the Inhibition of CYP3A4 and CYP2C19 Activity by Jabara Juice and Identification of the Responsible Inhibitory Components.\u201d<\/li>\n<li>Tomar, R., Ghodke, P.P., Patra, A., Smyth, E., Ponatarelli, A., Copp, W.\u00a0 Guengerich, F.P., Chaput, J.J., Wilds, C.J., Stone, M.P., and Egli, M. (2024) <i style=\"font-family: inherit;font-size: 16.0016px\">Biochemistry <\/i><i style=\"font-family: inherit;font-size: 16.0016px\">63<\/i>, 2425-2439. \u201cDNA Replication Across a-L-(3\u2032-2\u2032)-Threofuranosyl Nucleotides Mediated by Human DNA Polymerase eta.\u201d<\/li>\n<li>Tateishi, Y., McCarty, K.D., Martin, M.V., Yoshimoto, F.K., and Guengerich, F.P. (2024) <i style=\"font-family: inherit;font-size: 16.0016px\">Angew. Chem., Int. Ed. 63<\/i>, e202406542. \u201cRoles of Ferric Peroxide Anion Intermediates (Fe<span style=\"vertical-align: super;font-size: 16.0016px\">3+<\/span>O<span style=\"vertical-align: sub;font-size: 16.0016px\">2<\/span>\u00af) in Cytochrome P450 19A1 Steroid Aromatization and a Cytochrome P450 2B4 Secosteroid Model.\u201d<\/li>\n<li>Hargrove, T.Y., Lamb, D.C., Wawrazk, Z., Hull, M.T., Kelloy, S.L., La Scola, B., Guengerich, F.P., and Lepesheva, G.I. (2024) <i style=\"font-family: inherit;font-size: 16.0016px\">J. Med. Chem. 67<\/i>, 7443-7457. \u201cIdentification of Potent and Selective Inhibitors of <i style=\"font-family: inherit;font-size: 16.0016px\">Acanthamoeba<\/i>: Structural Insights into Sterol 14a-Demethylase as a Key Drug Target.&#8221;<\/li>\n<li>Uehara, S., Murayama, N., Higuchi, Y., Shimizu, M., Suemizu, H. Guengerich, F.P., and Yamazaki, H. (2024) <i style=\"font-family: inherit;font-size: 16.0016px\">Chem. Res. Toxicol. <\/i><em>37<\/em>, 671-674. \u201c<i style=\"font-family: inherit;font-size: 16.0016px\">In Vivo <\/i>and\n<div><i>In Vitro <\/i><span style=\"font-size: 16.0016px\">Induction of Cytochrome P450 3A4 by Thalidomide in Humanized-Liver Mice and Experimental Human Hepatocyte HepaSH Cells.\u201d<\/span><\/div>\n<\/li>\n<li>Tateishi, Y., McCarty, K.D., Martin, M.V., and Guengerich, F.P. (2024) <i><\/i><i>ACS Catalysis. <\/i><i style=\"font-family: inherit;font-size: 16.0016px\">14<\/i><i style=\"font-family: inherit;font-size: 16.0016px\">, <\/i>2388-2394.<span style=\"font-size: 16.0016px\"> \u201cOxygen-18 Labeling Defines a Ferric Peroxide (Compound 0) Mechanism in the Oxidative Deformylation of Aldehydes by Cytochrome P450 2B4.&#8221;<\/span><\/li>\n<li>Tateishi, Y., Webb, S.N., Li, B., Liu, L., Lindsey Rose, K., Leser, M., Patel, P., and Guengerich, F.P. (2024) <i>J. Biol. Chem. 300, 105688.<\/i> \u201cProteomics, Modeling, and Fluorescence Assays Delineate Cytochrome <i>b<\/i><sub>5<\/sub> Residues Involved in Binding and Stimulation of Cytochrome P450 17A1 Lyase.\u201d<\/li>\n<li>McCarty, K.D., Tateishi, Y., Hargrove, T.Y., Lepesheva, G.I., and Guengerich, F.P. (2024) <i>Angew. Chem., Int. Ed. <\/i>320231771 \u201cOxygen-18 Labeling Reveals a Mixed Fe-O Mechanism in Cytochrome P450 51A1 Sterol 14a-Demethylation.\u201d<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<p><strong>Review Articles<\/strong><\/p>\n<ul style=\"text-align: justify\">\n<li>Guengerich, F. P. (2026, in press)\u00a0in<i>\u00a0<\/i><i><span lang=\"EN-GB\">Recent Advances in Biotransformation of Drugs and Drug Candidates\u00a0<\/span><\/i><span lang=\"EN-GB\">(Isin, E.M., and Walles, M., Eds.) Wiley, New York.<\/span><span lang=\"EN-GB\">\u00a0<\/span>\u201cHistorical Perspective on Drug Metabolism.\u201d<\/li>\n<li>Norman, K.G., Kaufman, L.E., Greim, P., Loretz, L., Kowcz, A., Cohen, S.M., Scialli, A.R., Boobis, A.R., Jacobson-Kram, D., Schoeny, R., Rosol, T.J., Williams, G.M., Kaminski, N.E., Guengerich, F.P., and Nash, J.F. (2025)\u00a0<i>Crit. Rev. Toxicol.<\/i>\u00a055 (7), 716-734. \u201cComprehensive Review of Ensulizole Toxicology Data and Human Exposure Assessment for Personal Care Products.\u201d<\/li>\n<li>Norman, K.G., Kaufman, L.E., D\u2019Ruiz, C., Loretz, L., Kowcz, A., Cohen, S.M., Scialli, A.R., Boobis, A.R., Jacobson-Kram, D., Schoeny, R., Rosol, T.J., Williams, G.M., Kaminski, N.E., Guengerich, F.P., and Nash, J.F. (2025)\u00a0<i>Crit. Rev. Toxicol. 55\u00a0<\/i>(6), 662-692. doi: 10:1080\/10408444.2025.2535394.\u00a0\u201cComprehensive Review of Avobenzone\u00a0\u00a0Toxicology Data and Human Exposure Assessment for Personal Care Products.\u201d<\/li>\n<li>Cohen, S.M., Rietjens, I.M.C.M., Levy, L., Berry, C., Boffetta, P., Boobis, A.R., Calabrese, E.J., Clewell, H., Cope, R., Cox, T., Dellarco, V., Dietrich, D., Dourson, M., Eaton, D.L., Fukushima, S., Gooderham, N.J., Goodman, J.I., Gori, G., Greim, H., Guengerich, F.P., Hagen, T., Hengstler, J.G., Jacobson-Kram, D., Klaassen, C., Klaunig, J.E., Lang, S., McClellan, R. O., Nebert, D..W., Paustenbach, D., Ramos, K., Rosol, T.J., and Wallace, K.B. (2025)\u00a0<i>Toxicol. Sci.<\/i>\u00a0<i>206<\/i>, 1-3. \u201cChemical Risks and Children\u2019s Health: Building on Progress Based on Science, Not Panic.\u201d<\/li>\n<li>Cohen, S.M., Boobis, A.R., Jacobson-Kram, D., Schoeny, R., Rosol, T.J., Williams, G.M., Kaminski, N.E., Eichenbaum, G.M., Guengerich, F.P., and Nash, J.F. (2025)\u00a0<i>Crit. Rev. Toxicol. 55<\/i>, 248-284.\u00a0\u201cMode of Action Supports a Lack of Carcinogenic Potential of Six Organic UV Filters.\u201d DOI:10.1080\/10408444.2025.2462642.<\/li>\n<li>Guengerich, F.P. (2025, revised)\u00a0<i>Drug Metab. Rev<\/i>. \u201cSimplified Approaches to Kinetic Isotope Effects in Cytochrome P450-Catalyzed Reactions.\u201d<\/li>\n<li>Guengerich, F.P. (2024) <i style=\"font-family: inherit;font-size: 16.0016px\">J. Biol. Chem. 300, <\/i>105625. \u201cReflection: Ninety-eight Semesters of Cytochrome P450 Enzymes and Related Topics\u2014What Have I Taught and Learned?\u201d<\/li>\n<li>Guengerich, F.P. (2024) <i style=\"font-family: inherit;font-size: 16.0016px\">Pharmacol. Rev. <\/i><i style=\"font-family: inherit;font-size: 16.0016px\">76<\/i>, 1104-1132. \u201cRoles of Human Cytochrome P450 Enzymes in Drug Metabolism.\u201d<\/li>\n<li style=\"text-align: justify\">Rendic, S.P., and Guengerich, F.P. (2024) <i>Arch. Toxicol<\/i>. <em>98<\/em>, 1581-1628. \u201cBioactivation of Drugs to Potentially Toxic Products Catalyzed by Human Drug-Metabolizing Enzymes.\u201d<\/li>\n<li>Guengerich, F.P., Tateishi, Y., McCarty, K.D., and Yoshimoto, F.K. (2024) <i style=\"font-family: inherit;font-size: 16.0016px\">Int. J. Mol. Sci.<\/i><i style=\"font-family: inherit;font-size: 16.0016px\">25<\/i>, 9020. \u201cRecent Updates on Mechanisms of Cytochrome P450 Catalysis of Complex Steroid Oxidations.\u201d<\/li>\n<li style=\"text-align: justify\">Guengerich, F.P. (2024) <i>Drug Metab. Dispos. 52, <\/i>493-497<i>.<\/i> \u201cCytochrome P450 Enzymes as Drug Targets in Human Disease.\u201d<\/li>\n<\/ul>\n","protected":false},"excerpt":{"rendered":"<p>Recent Articles Zhu, Z., Chung, Y.-M., Alyamani, M., Dai, Y., McCarty, K.D., Roberts, E., Sinha, S., Li, J., Li, X., Gad, E.M., Zhou, C., Shi, J., Burgess, R.A., Hargrove, T.Y., Lepesheva, G.I., Guengerich, F.P., Auchus, R.J., and Sharifi, N. (2025)\u00a0Nature Commun.16, 10611.\u201cA Bypass Gateway from Cholesterol to Sex Steroid Biosynthesis.\u201d Elizondo, A.I., McCarty, K.D., Guengerich,&#8230;<\/p>\n","protected":false},"author":704,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"open","ping_status":"open","template":"","meta":{"footnotes":""},"tags":[],"class_list":["post-7","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/my.vanderbilt.edu\/guengerichlab\/wp-json\/wp\/v2\/pages\/7","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/my.vanderbilt.edu\/guengerichlab\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/my.vanderbilt.edu\/guengerichlab\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/my.vanderbilt.edu\/guengerichlab\/wp-json\/wp\/v2\/users\/704"}],"replies":[{"embeddable":true,"href":"https:\/\/my.vanderbilt.edu\/guengerichlab\/wp-json\/wp\/v2\/comments?post=7"}],"version-history":[{"count":106,"href":"https:\/\/my.vanderbilt.edu\/guengerichlab\/wp-json\/wp\/v2\/pages\/7\/revisions"}],"predecessor-version":[{"id":698,"href":"https:\/\/my.vanderbilt.edu\/guengerichlab\/wp-json\/wp\/v2\/pages\/7\/revisions\/698"}],"wp:attachment":[{"href":"https:\/\/my.vanderbilt.edu\/guengerichlab\/wp-json\/wp\/v2\/media?parent=7"}],"wp:term":[{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/my.vanderbilt.edu\/guengerichlab\/wp-json\/wp\/v2\/tags?post=7"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}