Mikael joined the Irish lab in August 2014 to train in advanced mass cytometry (CyTOF) and study regulatory myeloid and B lineage cells in the context of lymphoma and other hematological disorders.
Current: Assistant Professor, Faculty of Medicine, CHU Rennes, France.
Degrees: M.D., Ph.D. clinical biologist specialized in Cellular Hematology and his home institution is the University Hospital of Rennes, France.
Mikael’s manuscript in The Human Innate Immunity Handbook reviewed the defining features of human myeloid immune system cells from Elie Metchnikoff’s descriptions of phagocytes to the modern era of mass cytometry. This introduces Roussel et al., Journal of Leukocyte Biology 2017.
Mikael’s study in J Leukocyte Biology was the first mass cytometry study of human myeloid derived suppressor cells. Mass cytometry deep phenotyping and functional proliferation assays were used to characterize human blood and bone marrow mononuclear cells polarized under diverse cytokine conditions, including MDSCs and what was once called M1 and M2. [Selected for Cover]
Roussel M*, Ferrell PB, Greenplate AR, Lhomme F, Le Gallou S, Diggins KE, Johnson DB, Irish JM*. Mass cytometry deep phenotyping of human mononuclear phagocytes and myeloid-derived suppressor cells from human blood and bone marrow. Journal of Leukocyte Biology 2017 Aug;102(2):437-447. PMID: 28400539. PMCID in progress. Pubmed. DOI.