{"id":1049,"date":"2016-04-13T16:16:32","date_gmt":"2016-04-13T21:16:32","guid":{"rendered":"http:\/\/my.vanderbilt.edu\/irishlab\/?p=1049"},"modified":"2017-08-21T16:31:42","modified_gmt":"2017-08-21T21:31:42","slug":"1049","status":"publish","type":"post","link":"https:\/\/my.vanderbilt.edu\/irishlab\/2016\/04\/1049\/","title":{"rendered":"Published: Ferrell et al., PLOS One 2016"},"content":{"rendered":"<p style=\"text-align: justify\">Congratulations to <a href=\"http:\/\/my.vanderbilt.edu\/irishlab\/members\/irish-lab-alumni\/p-brent-ferrell-m-d\/\">Brent Ferrell<\/a> and co-authors on this publication!<\/p>\n<p style=\"text-align: justify\">Ferrell PB, Diggins KE, Polikowsky HG, Mohan SR, Seegmiller AC, Irish JM. <a href=\"https:\/\/scholar.google.com\/citations?view_op=view_citation&amp;hl=en&amp;user=-IJndUMAAAAJ&amp;cstart=20&amp;pagesize=80&amp;sortby=pubdate&amp;citation_for_view=-IJndUMAAAAJ:w0odbtu79TwC\">High-dimensional analysis of acute myeloid leukemia reveals phenotypic changes in persistent cells during induction therapy<\/a>. <strong>PLOS One<\/strong> 2016 Apr 13;11(4). <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC4830605\/\">PMC4830605<\/a>. <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/27074138\">Pubmed<\/a>. <a href=\"https:\/\/doi.org\/10.1371\/journal.pone.0153207\">DOI<\/a>.<\/p>\n<p style=\"text-align: justify\">\u25ba This peer-reviewed research study was the first to use mass cytometry to track human acute myeloid leukemia (AML) cells over time during therapy in patients.\u00a0 This study revealed dramatic remodeling of leukemia cell identity following chemotherapy treatment.\u00a0 <em>In vivo<\/em> observations showed that AML cells adopt a phenotype that is distinct from all other non-malignant immune cells, including healthy hematopoietic stem and progenitor cells.<\/p>\n<div id=\"attachment_551\" style=\"width: 2333px\" class=\"wp-caption aligncenter\"><img loading=\"lazy\" decoding=\"async\" aria-describedby=\"caption-attachment-551\" class=\"size-full wp-image-551\" src=\"https:\/\/cdn.vanderbilt.edu\/t2-my\/my-prd\/wp-content\/uploads\/sites\/424\/2014\/10\/2016-04-Ferrell-et-al.-Figure-7.jpg\" alt=\"2016 Ferrell et al. - PLOS ONE - High-Dimensional Analysis of Acute Myeloid Leukemia Reveals Phenotypic Changes in Persistent Cells during Induction Therapy\" width=\"2323\" height=\"1541\" srcset=\"https:\/\/cdn.vanderbilt.edu\/t2-my\/my-prd\/wp-content\/uploads\/sites\/424\/2014\/10\/2016-04-Ferrell-et-al.-Figure-7.jpg 2323w, https:\/\/cdn.vanderbilt.edu\/t2-my\/my-prd\/wp-content\/uploads\/sites\/424\/2014\/10\/2016-04-Ferrell-et-al.-Figure-7-300x199.jpg 300w, https:\/\/cdn.vanderbilt.edu\/t2-my\/my-prd\/wp-content\/uploads\/sites\/424\/2014\/10\/2016-04-Ferrell-et-al.-Figure-7-650x431.jpg 650w\" sizes=\"auto, (max-width: 2323px) 100vw, 2323px\" \/><p id=\"caption-attachment-551\" class=\"wp-caption-text\">2016 Ferrell et al. &#8211; PLOS ONE &#8211; High-Dimensional Analysis of Acute Myeloid Leukemia Reveals Phenotypic Changes in Persistent Cells during Induction Therapy<\/p><\/div>\n","protected":false},"excerpt":{"rendered":"<p>Congratulations to Brent Ferrell and co-authors on this publication! Ferrell PB, Diggins KE, Polikowsky HG, Mohan SR, Seegmiller AC, Irish JM. High-dimensional analysis of acute myeloid leukemia reveals phenotypic changes in persistent cells during induction therapy. PLOS One 2016 Apr &hellip; <a href=\"https:\/\/my.vanderbilt.edu\/irishlab\/2016\/04\/1049\/\">Continue reading <span class=\"meta-nav\">&rarr;<\/span><\/a><\/p>\n","protected":false},"author":565,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"footnotes":"","_links_to":"","_links_to_target":""},"categories":[7,1,6],"tags":[47,46,48,12,39],"class_list":["post-1049","post","type-post","status-publish","format-standard","hentry","category-irish-lab","category-news","category-publications","tag-acute-myeloid-leukemia","tag-aml","tag-induction-therapy","tag-mass-cytometry","tag-systems-immune-monitoring"],"_links":{"self":[{"href":"https:\/\/my.vanderbilt.edu\/irishlab\/wp-json\/wp\/v2\/posts\/1049","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/my.vanderbilt.edu\/irishlab\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/my.vanderbilt.edu\/irishlab\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/my.vanderbilt.edu\/irishlab\/wp-json\/wp\/v2\/users\/565"}],"replies":[{"embeddable":true,"href":"https:\/\/my.vanderbilt.edu\/irishlab\/wp-json\/wp\/v2\/comments?post=1049"}],"version-history":[{"count":4,"href":"https:\/\/my.vanderbilt.edu\/irishlab\/wp-json\/wp\/v2\/posts\/1049\/revisions"}],"predecessor-version":[{"id":1061,"href":"https:\/\/my.vanderbilt.edu\/irishlab\/wp-json\/wp\/v2\/posts\/1049\/revisions\/1061"}],"wp:attachment":[{"href":"https:\/\/my.vanderbilt.edu\/irishlab\/wp-json\/wp\/v2\/media?parent=1049"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/my.vanderbilt.edu\/irishlab\/wp-json\/wp\/v2\/categories?post=1049"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/my.vanderbilt.edu\/irishlab\/wp-json\/wp\/v2\/tags?post=1049"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}