{"id":1306,"date":"2018-01-03T15:46:05","date_gmt":"2018-01-03T20:46:05","guid":{"rendered":"http:\/\/my.vanderbilt.edu\/irishlab\/?p=1306"},"modified":"2018-05-08T15:38:25","modified_gmt":"2018-05-08T20:38:25","slug":"published-earl-ferrell-et-al-nature-communications-2018","status":"publish","type":"post","link":"https:\/\/my.vanderbilt.edu\/irishlab\/2018\/01\/published-earl-ferrell-et-al-nature-communications-2018\/","title":{"rendered":"Published: Earl & Ferrell et al.,\u00a0Nature Communications 2018"},"content":{"rendered":"

Congratulations to David Earl & Brent Ferrell<\/a>, co-first authors, and\u00a0co-author Nalin Leelatian<\/a> for their\u00a0work that just came out in Nature Communications<\/em>!<\/p>\n

Earl DC*, Ferrell PB*, Leelatian N, Froese J, Reisman B, Irish JM**, Bachmann BO**. Discovery of human cell selective effector molecules using single cell multiplexed activity metabolomics. Nature Communications <\/strong> DOI<\/a>. *equal contribution. **co-corresponding authors.<\/p>\n

\u25ba This peer-reviewed research developed out of a collaborative Vanderbilt University Discovery pilot grant that brought together the Irish lab\u2019s expertise in acute myeloid leukemia (AML) and single cell tools and the Bachmann lab\u2019s expertise in identifying novel metabolite effectors.\u00a0 This work created a novel single cell metabolomics platform that uses primary human tissue biopsies and applied it in AML to identify and characterize a novel natural product that selectively targets leukemia cells and spares non-malignant monocytes and lymphocytes from the bone marrow microenvironment.<\/p>\n

\"2018

2018 Earl and Ferrell et al. Figure 1<\/p><\/div>\n

This work was written up<\/a> on the Vanderbilt Institute for Chemical Biology (VICB) page here:<\/p>\n

\"The

The Power of Multiplexed Activity Metabolomics<\/a>
January 17, 2018<\/p><\/div>\n

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This work was also written up by Research News @ Vanderbilt:<\/p>\n

https:\/\/news.vanderbilt.edu\/2018\/05\/01\/looking-beyond-the-magic-bullet-approach-to-drug-discovery\/<\/p>\n

\"Bachmann,

The Team, from left to right: Jonathan Irish, David Earl, Brent Ferrell, the CyTOF mass cytometer, and Brian Bachmann (photo by John Russell\/Vanderbilt University)<\/p><\/div>\n

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This work follows prior\u00a0work from Garry Nolan’s lab by Peter Krutzik et al., Nature Chemical Biology<\/em> 2008 (DOI<\/a>), showing the power of the single cell chemical biology approach, and by Bernd Bodenmiller et al., Nature Biotechnology<\/em> 2013 (DOI<\/a>),\u00a0developing mass cytometry assays for chemical biology.<\/p>\n

For more information about using this system at Vanderbilt, please contact the Cancer & Immunology Core (CIC<\/a>).<\/p>\n

 <\/p>\n","protected":false},"excerpt":{"rendered":"

Congratulations to David Earl & Brent Ferrell, co-first authors, and\u00a0co-author Nalin Leelatian for their\u00a0work that just came out in Nature Communications! Earl DC*, Ferrell PB*, Leelatian N, Froese J, Reisman B, Irish JM**, Bachmann BO**. Discovery of human cell selective … Continue reading →<\/span><\/a><\/p>\n","protected":false},"author":565,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"footnotes":"","_links_to":"","_links_to_target":""},"categories":[1],"tags":[],"class_list":["post-1306","post","type-post","status-publish","format-standard","hentry","category-news"],"_links":{"self":[{"href":"https:\/\/my.vanderbilt.edu\/irishlab\/wp-json\/wp\/v2\/posts\/1306","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/my.vanderbilt.edu\/irishlab\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/my.vanderbilt.edu\/irishlab\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/my.vanderbilt.edu\/irishlab\/wp-json\/wp\/v2\/users\/565"}],"replies":[{"embeddable":true,"href":"https:\/\/my.vanderbilt.edu\/irishlab\/wp-json\/wp\/v2\/comments?post=1306"}],"version-history":[{"count":12,"href":"https:\/\/my.vanderbilt.edu\/irishlab\/wp-json\/wp\/v2\/posts\/1306\/revisions"}],"predecessor-version":[{"id":1377,"href":"https:\/\/my.vanderbilt.edu\/irishlab\/wp-json\/wp\/v2\/posts\/1306\/revisions\/1377"}],"wp:attachment":[{"href":"https:\/\/my.vanderbilt.edu\/irishlab\/wp-json\/wp\/v2\/media?parent=1306"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/my.vanderbilt.edu\/irishlab\/wp-json\/wp\/v2\/categories?post=1306"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/my.vanderbilt.edu\/irishlab\/wp-json\/wp\/v2\/tags?post=1306"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}