Publications

2019

GRIK5 Genetically Regulated Expression Associated with Eye and Vascular Phenomes: Discovery through Iteration among Biobanks, Electronic Health Records, and Zebrafish.

Unlu G, Gamazon ER, Qi X, Levic DS, Bastarache L, Denny JC, Roden DM, Mayzus I, Breyer M, Zhong X, Konkashbaev AI, Rzhetsky A, Knapik EW, Cox NJ.

Am J Hum Genet. 2019 Mar 7;104(3):503-519. doi: 10.1016/j.ajhg.2019.01.017. Epub 2019 Feb 28. PMID: 30827500

2018

Dynamic Glycosylation Governs the Vertebrate COPII Protein Trafficking Pathway.

Cox NJ, Unlu G, Bisnett BJ, Meister TR, Condon BM, Luo PM, Smith TJ, Hanna M, Chhetri A, Soderblom EJ, Audhya A, Knapik EW, Boyce M.

Biochemistry. 2018 Jan 9;57(1):91-107. doi: 10.1021/acs.biochem.7b00870. Epub 2017 Dec 15. PMID: 29161034

2017

Evolution of the hypoxia-sensitive cells involved in amniote respiratory reflexes.

Hockman D, Burns AJ, Schlosser G, Gates KP, Jevans B, Mongera A, Fisher S, Unlu G, Knapik EW, Kaufman CK, Mosimann C, Zon LI, Lancman JJ, Dong PDS, Lickert H, Tucker AS, Baker CV.

Elife. 2017 Apr 7;6. pii: e21231. doi: 10.7554/eLife.21231. PMID: 28387645

Zebrafish Developmental Models of Skeletal Diseases.

Luderman LN, Unlu G, Knapik EW.

Curr Top Dev Biol. 2017;124:81-124. doi: 10.1016/bs.ctdb.2016.11.004. Epub 2017 Jan 4. Review. PMID: 28335865

2015

Animal model of Sar1b deficiency presents lipid absorption deficits similar to Anderson disease.

Levic DS, Minkel JR, Wang WD, Rybski WM, Melville DB, Knapik EW.

J Mol Med (Berl). 2015 Feb;93(2):165-76. doi: 10.1007/s00109-014-1247-x. Epub 2015 Jan 7. PMID: 25559265

2014

Gremlin 2 promotes differentiation of embryonic stem cells to atrial fate by activation of the JNK signaling pathway.

Tanwar V, Bylund JB, Hu J, Yan J, Walthall JM, Mukherjee A, Heaton WH, Wang WD, Potet F, Rai M, Kupershmidt S, Knapik EW, Hatzopoulos AK.

Stem Cells. 2014 Jul;32(7):1774-88. doi: 10.1002/stem.1703. PMID: 24648383

The nuclear pore complex function of Sec13 protein is required for cell survival during retinal development.

Niu X, Hong J, Zheng X, Melville DB, Knapik EW, Meng A, Peng J.

J Biol Chem. 2014 Apr 25;289(17):11971-85. doi: 10.1074/jbc.M114.547190. Epub 2014 Mar 13. PMID: 24627485

In vivo cell biology in zebrafish – providing insights into vertebrate development and disease.

Vacaru AM, Unlu G, Spitzner M, Mione M, Knapik EW, Sadler KC.

J Cell Sci. 2014 Feb 1;127(Pt 3):485-95. doi: 10.1242/jcs.140194. Review. PMID: 24481493

Trafficking mechanisms of extracellular matrix macromolecules: insights from vertebrate development and human diseases.

Unlu G, Levic DS, Melville DB, Knapik EW.

Int J Biochem Cell Biol. 2014 Feb;47:57-67. doi: 10.1016/j.biocel.2013.11.005. Epub 2013 Dec 9. Review. PMID: 24333299

The NADH oxidase ENOX1, a critical mediator of endothelial cell radiosensitization, is crucial for vascular development.

Venkateswaran A, Sekhar KR, Levic DS, Melville DB, Clark TA, Rybski WM, Walsh AJ, Skala MC, Crooks PA, Knapik EW, Freeman ML.

Cancer Res. 2014 Jan 1;74(1):38-43. doi: 10.1158/0008-5472.CAN-13-1981. Epub 2013 Nov 18. PMID: 24247717

2013

An exclusively mesodermal origin of fin mesenchyme demonstrates that zebrafish trunk neural crest does not generate ectomesenchyme.

Lee RT, Knapik EW, Thiery JP, Carney TJ.

Development. 2013 Jul;140(14):2923-32. doi: 10.1242/dev.093534. Epub 2013 Jun 5. PMID: 23739134

Functional modeling in zebrafish demonstrates that the atrial-fibrillation-associated gene GREM2 regulates cardiac laterality, cardiomyocyte differentiation and atrial rhythm.

Müller II, Melville DB, Tanwar V, Rybski WM, Mukherjee A, Shoemaker MB, Wang WD, Schoenhard JA, Roden DM, Darbar D, Knapik EW, Hatzopoulos AK.

Dis Model Mech. 2013 Mar;6(2):332-41. doi: 10.1242/dmm.010488. Epub 2012 Dec 7. PMID: 23223679

2011

An SNP-Based Linkage Map for Zebrafish Reveals Sex Determination Loci.

Bradley KM, Breyer JP, Melville DB, Broman KW, Knapik EW, Smith JR.

G3 (Bethesda). 2011 Jun 1;1(1):3-9. PMID: 21949597

Mutations in fam20b and xylt1 reveal that cartilage matrix controls timing of endochondral ossification by inhibiting chondrocyte maturation.

Eames BF, Yan YL, Swartz ME, Levic DS, Knapik EW, Postlethwait JH, Kimmel CB.

PLoS Genet. 2011 Aug;7(8):e1002246. doi: 10.1371/journal.pgen.1002246. Epub 2011 Aug 25. PMID: 21901110

The feelgood mutation in zebrafish dysregulates COPII-dependent secretion of select extracellular matrix proteins in skeletal morphogenesis.

Melville DB, Montero-Balaguer M, Levic DS, Bradley K, Smith JR, Hatzopoulos AK, Knapik EW.

Dis Model Mech. 2011 Nov;4(6):763-76. doi: 10.1242/dmm.007625. Epub 2011 Jul 4. PMID: 21729877

Tumor suppressor Lzap regulates cell cycle progression, doming, and zebrafish epiboly.

Liu D, Wang WD, Melville DB, Cha YI, Yin Z, Issaeva N, Knapik EW, Yarbrough WG.

Dev Dyn. 2011 Jun;240(6):1613-25. doi: 10.1002/dvdy.22644. Epub 2011 Apr 26. PMID: 21523853

Traffic jams in fish bones: ER-to-Golgi protein transport during zebrafish development.

Melville DB, Knapik EW.

Cell Adh Migr. 2011 Mar-Apr;5(2):114-8. Epub 2011 Mar 1. Review. PMID: 21178403

2010

Sec24D-dependent transport of extracellular matrix proteins is required for zebrafish skeletal morphogenesis.

Sarmah S, Barrallo-Gimeno A, Melville DB, Topczewski J, Solnica-Krezel L, Knapik EW.

PLoS One. 2010 Apr 28;5(4):e10367. doi: 10.1371/journal.pone.0010367. PMID: 20442775

2009

A selective glial barrier at motor axon exit points prevents oligodendrocyte migration from the spinal cord.

Kucenas S, Wang WD, Knapik EW, Appel B.

J Neurosci. 2009 Dec 2;29(48):15187-94. doi: 10.1523/JNEUROSCI.4193-09.2009. PMID: 19955371

2008

Goodpasture antigen-binding protein and its spliced variant, ceramide transfer protein, have different functions in the modulation of apoptosis during zebrafish development.

Granero-Moltó F, Sarmah S, O’Rear L, Spagnoli A, Abrahamson D, Saus J, Hudson BG, Knapik EW.

J Biol Chem. 2008 Jul 18;283(29):20495-504. doi: 10.1074/jbc.M801806200. Epub 2008 Apr 18. PMID: 18424781

2007

A major zebrafish polymorphism resource for genetic mapping.

Bradley KM, Elmore JB, Breyer JP, Yaspan BL, Jessen JR, Knapik EW, Smith JR.

Genome Biol. 2007;8(4):R55. PMID: 17428331

2006

The mother superior mutation ablates foxd3 activity in neural crest progenitor cells and depletes neural crest derivatives in zebrafish.

Montero-Balaguer M, Lang MR, Sachdev SW, Knappmeyer C, Stewart RA, De La Guardia A, Hatzopoulos AK, Knapik EW.

Dev Dyn. 2006 Dec;235(12):3199-212. PMID: 17013879

Secretory COPII coat component Sec23a is essential for craniofacial chondrocyte maturation.

Lang MR, Lapierre LA, Frotscher M, Goldenring JR, Knapik EW.

Nat Genet. 2006 Oct;38(10):1198-203. Epub 2006 Sep 17. PMID: 16980978

Expression of the protein related to Dan and Cerberus gene–prdc–During eye, pharyngeal arch, somite, and swim bladder development in zebrafish.

Müller II, Knapik EW, Hatzopoulos AK.

Dev Dyn. 2006 Oct;235(10):2881-8. PMID: 16921498

2004

Neural crest survival and differentiation in zebrafish depends on mont blanc/tfap2a gene function.

Barrallo-Gimeno A, Holzschuh J, Driever W, Knapik EW.

Development. 2004 Apr;131(7):1463-77. Epub 2004 Feb 25. PMID: 14985255