Protein damage response network for 4-hydroxynonenal (from Zhang et al. (2011) Mol. Biosyst. 7: 2018-2027)

Research in the Liebler Laboratory applies chemistry, mass spectrometry, proteomics and bioinformatics to solve problems in chemical biology, toxicology and cancer research.  Our work is highly interdisciplinary and involves collaborations with basic scientists and clinicians at Vanderbilt and leading research institutions around the United States.  Much of our work is closely coordinated with the Jim Ayers Institute, which is directed by Dr. Liebler.

Major themes of our work are 1) the exploration of cancer biology and discovery of new cancer diagnostics and 2) the elucidation of mechanisms by which reactive electrophilic chemicals cause toxicity.  This work is funded by the National Institutes of Health and by other US federal agencies and by pharmaceutical industry partners.  Training opportunities are available for graduate and postdoctoral studies.  Vanderbilt provides an exciting, collaborative environment and outstanding infrastructure for our work.