Surprising stability of plasma proteins for targeted proteomic analysis

Biospecimen quality is a major problem in biomarker development research.  Many biomolecules are known to be labile under conditions of sample collection, processing and storage, particularly when delays allow degradation.  These preanalytical variables are often poorly controlled or documented, but they could significantly impact on sample quality and biomarker measurements.  Previous work in several laboratories…

Posted by Daniel Liebler on June 26, 2012 in News

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A protein expression signature for drug response

Graduate student Matt Myers’ dissertation project asked the question, “Can protein expression changes indicate responses to drug inhibition of a signaling network?”  Matt’s recent paper in Molecular and Cellular Proteomics studied epidermal growth factor receptor (EGFR) signaling, which is the target of several anticancer drugs.  He used shotgun proteomic analysis to compare the proteomes of…

Posted by Daniel Liebler on February 24, 2012 in News

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