Can We Get Around the Crossing Fiber Problem by Increasing Spatial resolution?
Kurt G. Schilling, Vaibhav Janve, Yurui Gao, Iwona Stepniewska, Bennett A. Landman, Adam W Anderson. “Can We Get Around the Crossing Fiber Problem by Increasing Spatial resolution?” In Proceedings of the ISMRM Workshop on Diffusion MRI. Lisbon, Portugal, September 2016. Oral presentation.
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It is now widely recognized that voxels with crossing fibers and complex configurations present a challenge for diffusion MRI (dMRI) reconstruction and fiber tracking algorithms. This “crossing fiber” problem has been estimated to affect anywhere from 30%  to 90%  of white matter (WM) voxels, and it is generally assumed that increasing the spatial resolution as much as possible will minimize the number of voxels containing multiple fiber populations. Here, using both dMRI and histology from the same brain, we investigate the prevalence of this crossing fiber problem across a range of spatial resolutions.