{"id":1960,"date":"2018-12-15T11:55:38","date_gmt":"2018-12-15T16:55:38","guid":{"rendered":"https:\/\/my.vanderbilt.edu\/masi\/?p=1960"},"modified":"2018-12-19T16:55:16","modified_gmt":"2018-12-19T21:55:16","slug":"confirmation-of-a-gyral-bias-in-diffusion-mri-fiber-tractography","status":"publish","type":"post","link":"https:\/\/my.vanderbilt.edu\/masi\/2018\/12\/confirmation-of-a-gyral-bias-in-diffusion-mri-fiber-tractography\/","title":{"rendered":"Confirmation of a Gyral Bias in Diffusion MRI Fiber Tractography"},"content":{"rendered":"

Kurt G Schilling, Yurui Gao, Iwona Stepniewska, Bennett A. Landman, and Adam W Anderson. \u201cConfirmation of a Gyral Bias in Diffusion MRI Fiber Tractography\u201d. Human Brain Mapping. 2018 Mar;39(3):1449-1466. doi: 10.1002\/hbm.23936.<\/p>\n

Full text: https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/?term=Confirmation+of+a+Gyral+Bias+in+Diffusion+MRI+Fiber+Tractography<\/strong><\/p>\n

Abstract<\/h2>\n

Diffusion<\/span> MRI<\/span> fiber<\/span> tractography<\/span> has been increasingly used to map the structural connectivity of the human brain. However, this technique is not without limitations; for example, there is a growing concern over anatomically correlated bias<\/span> in tractography<\/span> findings. In this study, we demonstrate that there is a bias<\/span> for fiber<\/span> tracking algorithms to terminate preferentially on gyral<\/span> crowns, rather than the banks of sulci. We investigate this issue by comparing diffusion<\/span> MRI<\/span> (dMRI) tractography<\/span> with equivalent measures made on myelin-stained histological sections. We begin by investigating the orientation and trajectories of axons near the white matter\/gray matter boundary, and the density of axons entering the cortex at different locations along gyral<\/span> blades. These results are compared with dMRI orientations and tract densities at the same locations, where we find a significant gyral<\/span> bias<\/span> in many gyral<\/span> blades across the brain. This effect is shown for a range of tracking algorithms, both deterministic and probabilistic, and multiple diffusion<\/span> models, including the diffusion<\/span> tensor and a high angular resolution diffusion<\/span> imaging technique. Additionally, the gyral<\/span> bias<\/span> occurs for a range of diffusion<\/span>weightings, and even for very high-resolution datasets. The bias<\/span> could significantly affect connectivity results using the current generation of tracking algorithms.<\/p>\n

Keywords:<\/b><\/p>\n

brain; connectivity; diffusion<\/span> MRI<\/span>; gyral<\/span> bias<\/span>; histology; tractography<\/span>; validation<\/p>\n

\"Subset
Subset of DTI streamlines for each tracking strategy. Labels for crown, wall, and fundi are shown with a zoomed in view of the SFG. DTI streamlines are shown for M1 (whole brain seeding), M2 (WM seeding), and M3 (WMGM boundary seeding), and are colored based on streamline orientation. The dashed arrow highlights a fundus, where no streamlines are able to propagate. The solid arrow points toward the increased curvature of streamlines entering the GM. And the oval highlights a large, homogenous, area of WM, where seeding will contribute to over\u2010representation of fibers terminating at the crown<\/figcaption><\/figure>\n","protected":false},"excerpt":{"rendered":"

Kurt G Schilling, Yurui Gao, Iwona Stepniewska, Bennett A. Landman, and Adam W Anderson. \u201cConfirmation of a Gyral Bias in Diffusion MRI Fiber Tractography\u201d. Human Brain Mapping. 2018 Mar;39(3):1449-1466. doi: 10.1002\/hbm.23936. Full text: https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/?term=Confirmation+of+a+Gyral+Bias+in+Diffusion+MRI+Fiber+Tractography Abstract Diffusion MRI fiber tractography has been increasingly used to map the structural connectivity of the human brain. However, this technique…<\/p>\n","protected":false},"author":6324,"featured_media":1961,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[124,33,9,1,49],"tags":[],"class_list":["post-1960","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-crossing-fibers","category-diffusion-tensor-imaging","category-diffusion-weighted-mri","category-news","category-tractography"],"_links":{"self":[{"href":"https:\/\/my.vanderbilt.edu\/masi\/wp-json\/wp\/v2\/posts\/1960","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/my.vanderbilt.edu\/masi\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/my.vanderbilt.edu\/masi\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/my.vanderbilt.edu\/masi\/wp-json\/wp\/v2\/users\/6324"}],"replies":[{"embeddable":true,"href":"https:\/\/my.vanderbilt.edu\/masi\/wp-json\/wp\/v2\/comments?post=1960"}],"version-history":[{"count":1,"href":"https:\/\/my.vanderbilt.edu\/masi\/wp-json\/wp\/v2\/posts\/1960\/revisions"}],"predecessor-version":[{"id":1962,"href":"https:\/\/my.vanderbilt.edu\/masi\/wp-json\/wp\/v2\/posts\/1960\/revisions\/1962"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/my.vanderbilt.edu\/masi\/wp-json\/wp\/v2\/media\/1961"}],"wp:attachment":[{"href":"https:\/\/my.vanderbilt.edu\/masi\/wp-json\/wp\/v2\/media?parent=1960"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/my.vanderbilt.edu\/masi\/wp-json\/wp\/v2\/categories?post=1960"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/my.vanderbilt.edu\/masi\/wp-json\/wp\/v2\/tags?post=1960"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}