Abstract<\/h2>\n
<\/p>\n
Purpose:<\/strong>\u00a0One of the key challenges of the manual delineation\u00a0of white matter pathways is human-rater’s subjectivity in labeling. Clearly communicating the manual processes to capture this information is cumbersome, yet essential to lay a solid foundation for comprehensive atlases. Segmentation protocols must be designed so the interpretation of the requested tasks as well as locating structural landmarks is anatomically accurate, intuitive and reproducible.<\/p>\n Methods:<\/strong>\u00a0In this work, we quantified the reproducibility of a first iteration of an open\/public multi-bundle segmentation protocol. This allowed us to establish a baseline for its reproducibility as well as to identify the limitations for future iterations. The protocol was tested\/evaluated on both typical 3\u00a0T research acquisition Baltimore Longitudinal Study of Aging (BLSA) and high-acquisition quality Human\u00a0Connectome\u00a0Project (HCP) datasets.<\/p>\n Results:<\/strong>\u00a0The results show that a rudimentary protocol can produce acceptable intra-rater and inter-rater reproducibility. However, this work highlights the difficulty in generalizing reproducible results and the importance of reaching a consensus on the anatomical description of white matter pathways.<\/p>\n Conclusions:<\/strong>\u00a0The protocol has been made available in open source to improve generalizability and reliability in collaboration. The goal is to improve upon the first iteration and initiate a discussion on the anatomical validity (or lack thereof) of some bundle definitions and the importance of reproducibility of\u00a0tractography\u00a0segmentation.<\/p>\n <\/p>\n Rheault, Francois, Roza G. Bayrak, Xuan Wang, Kurt G. Schilling, Jasmine M. Greer, Colin B. Hansen, Cailey Kerley et al. “TractEM: Evaluation of protocols for deterministic tractography white matter atlas.”\u00a0Magnetic Resonance Imaging\u00a085 (2022): 44-56. Full Text Abstract Purpose:\u00a0One of the key challenges of the manual delineation\u00a0of white matter pathways is human-rater’s subjectivity in labeling….<\/p>\n","protected":false},"author":9372,"featured_media":2868,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[9,3,114,82,40,49],"tags":[],"class_list":["post-2867","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-diffusion-weighted-mri","category-image-segmentation","category-labeling","category-magnetic-resonance-imaging","category-reproducibility","category-tractography"],"_links":{"self":[{"href":"https:\/\/my.vanderbilt.edu\/masi\/wp-json\/wp\/v2\/posts\/2867","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/my.vanderbilt.edu\/masi\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/my.vanderbilt.edu\/masi\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/my.vanderbilt.edu\/masi\/wp-json\/wp\/v2\/users\/9372"}],"replies":[{"embeddable":true,"href":"https:\/\/my.vanderbilt.edu\/masi\/wp-json\/wp\/v2\/comments?post=2867"}],"version-history":[{"count":2,"href":"https:\/\/my.vanderbilt.edu\/masi\/wp-json\/wp\/v2\/posts\/2867\/revisions"}],"predecessor-version":[{"id":2969,"href":"https:\/\/my.vanderbilt.edu\/masi\/wp-json\/wp\/v2\/posts\/2867\/revisions\/2969"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/my.vanderbilt.edu\/masi\/wp-json\/wp\/v2\/media\/2868"}],"wp:attachment":[{"href":"https:\/\/my.vanderbilt.edu\/masi\/wp-json\/wp\/v2\/media?parent=2867"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/my.vanderbilt.edu\/masi\/wp-json\/wp\/v2\/categories?post=2867"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/my.vanderbilt.edu\/masi\/wp-json\/wp\/v2\/tags?post=2867"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}![\"Average](\"https:\/\/my.vanderbilt.edu\/masi\/wp-content\/uploads\/sites\/2304\n2661\/2021\/12\/overview_variability-476x650.png\")
<\/p>\n","protected":false},"excerpt":{"rendered":"