{"id":6,"date":"2017-07-10T21:45:02","date_gmt":"2017-07-10T21:45:02","guid":{"rendered":"https:\/\/my.vanderbilt.edu\/plateresearch\/publications\/"},"modified":"2019-03-08T01:33:33","modified_gmt":"2019-03-08T01:33:33","slug":"publications","status":"publish","type":"page","link":"https:\/\/my.vanderbilt.edu\/plateresearch\/publications\/","title":{"rendered":"Publications"},"content":{"rendered":"
    \n
  1. Blackwood EA, Azizi K, Thuerauf DJ, Paxman RJ,\u00a0Plate<\/b>\u00a0L<\/strong>, Kelly JW,\u00a0Wiseman\u00a0RL, Glembotski CC.\u00a0Pharmacologic ATF6 activation confers global protection in widespread disease models by reprograming cellular proteostasis<\/em>.\u00a0Nat Commun<\/span>. 2019 10(1):187. doi:\u00a010.1038\/s41467-018-08129-2<\/a><\/li>\n
  2. Grandjean JM<\/span><\/span>,\u00a0Plate L<\/span><\/span><\/strong>,\u00a0Morimoto RI<\/span><\/span>,\u00a0Bollong MJ<\/span><\/span>,\u00a0Powers ET<\/span><\/span>,\u00a0Wiseman RL.\u00a0Deconvoluting Stress-Responsive Proteostasis Signaling Pathways for Pharmacologic Activation using Targeted RNA-sequencing. <\/span><\/em>in print at ACS Chemical Biology,\u00a0<\/span>BioRxiv. Dec. 2018. doi:\u00a0https:\/\/doi.org\/10.1101\/499046<\/a><\/span><\/span><\/span><\/li>\n
  3. [PREPRINT<\/em>] Plate, L<\/strong>, Rius, B, Nguyen B, Genereux JC, Kelly, JW, Wiseman, RL. Quantitative Interactome Proteomics Reveals a Molecular Basis for ATF6-Dependent Regulation of a Destabilized Amyloidogenic Protein<\/em>. BioRxiv. July 2018. doi:\u00a0https:\/\/doi.org\/10.1101\/381525<\/a><\/li>\n
  4. Paxman, RJ,\u00a0Plate, L<\/strong>,\u00a0Blackwood EA, Glembotski, CC, Powers, ET, Wiseman, RL, Kelly, JW. A Small Molecule that Preferentially Activates the ATF6 Pathway of the Unfolded Protein Response is Metabolically Activated to Selectively Modify Endoplasmic Reticulum Proteins.\u00a0<\/em>Elife. 2018\u00a07:\u00a0e37168. doi:\u00a010.7554\/eLife.37168<\/a><\/li>\n
  5. Kroeger H, Grimsey N, Paxman R, Chiang WC,\u00a0Plate L<\/b>, Jones Y, Shaw PX, Trejo J, Tsang SH, Powers E, Kelly JW, Wiseman RL, Lin JH.\u00a0The unfolded protein response regulator ATF6 promotes mesodermal differentiation.<\/em>\u00a0Sci Signal<\/span>. 2018 11(517). pii: eaan5785.\u00a0doi: 10.1126\/scisignal.aan5785<\/a><\/li>\n
  6. Mortenson DE, Brighty GJ,\u00a0Plate L<\/b>, Bare G, Chen W, Li S, Wang H, Cravatt BF, Forli S, Powers ET, Sharpless KB, Wilson IA, Kelly JW.\u00a0“Inverse Drug Discovery” Strategy To Identify Proteins That Are Targeted by Latent Electrophiles As Exemplified by Aryl Fluorosulfates.<\/em>\u00a0J Am Chem Soc<\/span>. 2018 140(1): 200-210. doi: 10.1021\/jacs.7b08366<\/a><\/li>\n
  7. Schonhoft JD, Monteiro C,\u00a0Plate L<\/b>, Eisele YS, Kelly JM, Boland D, Parker CG, Cravatt BF, Teruya S, Helmke S, Maurer M, Berk J, Sekijima Y, Novais M, Coelho T, Powers ET, Kelly JW.\u00a0Peptide probes detect misfolded transthyretin oligomers in plasma of hereditary amyloidosis patients.<\/em>\u00a0Sci Transl Med<\/span>. 2017 407 pii: eaam7621.\u00a0doi: 10.1126\/scitranslmed.aam7621<\/a><\/li>\n
  8. Chen KC, Qu S, Chowdhury S, Noxon IC, Schonhoft JD, Plate L<\/strong>, Powers ET, Kelly
    \nJW, Lander GC, Wiseman RL. The endoplasmic reticulum HSP40 co-chaperone<\/em>
    \n ERdj3\/DNAJB11 assembles and functions as a tetramer.<\/em> EMBO J. 2017 36(15). pii:
    \ne201695616. doi:     10.15252\/embj.201695616<\/a>.<\/li>\n
  9. \u00a0Plate L<\/strong>, Wiseman RL. Regulating Secretory Proteostasis through the Unfolded<\/em>
    \n Protein Response: From Function to Therapy.<\/em> Trends Cell Biol. 2017 Jun 21. pii:
    \nS0962-8924(17)30085-5. doi:     10.1016\/j.tcb.2017.05.006<\/a>. [Epub ahead of print]<\/li>\n
  10. Alvarez-Garcia O, Matsuzaki T, Olmer M, Plate L<\/strong>, Kelly JW, Lotz MK. Regulated<\/em>
    \n in Development and DNA Damage Response 1 Deficiency Impairs Autophagy and<\/em>
    \n Mitochondrial Biogenesis in Articular Cartilage and Increases the Severity of<\/em>
    \n Experimental Osteoarthritis.<\/em> Arthritis Rheumatol. 2017 69 (7):1418-1428. doi:
    \n    10.1002\/art.40104<\/a>.<\/li>\n
  11. Plate L<\/strong>, Cooley CB, Chen JJ, Paxman RJ, Gallagher CM, Madoux F, Genereux JC,
    \nDobbs W, Garza D, Spicer TP, Scampavia L, Brown SJ, Rosen H, Powers ET, Walter P,
    \nHodder P, Wiseman RL, Kelly JW. Small molecule proteostasis regulators that<\/em>
    \n reprogram the ER to reduce extracellular protein aggregation.<\/em> Elife. 2016 Jul
    \n20;5. pii: e15550. doi:     10.7554\/eLife.15550<\/a>.<\/li>\n
  12. Plate L<\/strong>, Paxman RJ, Wiseman RL, Kelly JW. Modulating protein quality control.<\/em>
    \nElife. 2016 Jul 20;5. pii: e18431. doi:     10.7554\/eLife.18431<\/a>.<\/li>\n
  13. Chen W, Dong J, Plate L<\/strong>, Mortenson DE, Brighty GJ, Li S, Liu Y, Galmozzi A,
    \nLee PS, Hulce JJ, Cravatt BF, Saez E, Powers ET, Wilson IA, Sharpless KB, Kelly
    \nJW. Arylfluorosulfates Inactivate Intracellular Lipid Binding Protein(s) through<\/em>
    \n Chemoselective SuFEx Reaction with a Binding Site Tyr Residue.<\/em> J Am Chem Soc.
    \n2016 Jun 15;138(23):7353-64. doi:     10.1021\/jacs.6b02960<\/a>.<\/li>\n
  14. Cooley CB, Ryno LM, Plate L<\/strong>, Morgan GJ, Hulleman JD, Kelly JW, Wiseman RL.
    \nUnfolded protein response activation reduces secretion and extracellular<\/em>
    \n aggregation of amyloidogenic immunoglobulin light chain.<\/em> Proc Natl Acad Sci U S
    \nA. 2014 Sep 9;111(36):13046-51. doi:     10.1073\/pnas.1406050111<\/a>.<\/li>\n
  15. Plate L<\/strong>, Marletta MA. Phosphorylation-dependent derepression by the response<\/em>
    \n regulator HnoC in the Shewanella oneidensis nitric oxide signaling network.<\/em> Proc
    \nNatl Acad Sci U S A. 2013 Nov 26;110(48):E4648-57. doi:     10.1073\/pnas.1318128110<\/a>.<\/li>\n
  16. Plate L<\/strong>, Marletta MA. Nitric oxide-sensing H-NOX proteins govern bacterial<\/em>
    \n communal behavior.<\/em> Trends Biochem Sci. 2013 Nov;38(11):566-75. doi:
    \n    10.1016\/j.tibs.2013.08.008<\/a>.<\/li>\n
  17. Ivanisevic J, Zhu ZJ, Plate L<\/strong>, Tautenhahn R, Chen S, O’Brien PJ, Johnson CH,
    \nMarletta MA, Patti GJ, Siuzdak G. Toward ‘omic scale metabolite profiling: a dual<\/em>
    \n separation-mass spectrometry approach for coverage of lipid and central carbon<\/em>
    \n metabolism.<\/em> Anal Chem. 2013 Jul 16;85(14):6876-84. doi:     10.1021\/ac401140h<\/a>.<\/li>\n
  18. Plate L<\/strong>, Marletta MA. Nitric oxide modulates bacterial biofilm formation<\/em>
    \n through a multicomponent cyclic-di-GMP signaling network.<\/em> Mol Cell. 2012 May
    \n25;46(4):449-60. doi:     10.1016\/j.molcel.2012.03.023<\/a>.<\/li>\n
  19. Weinert EE, Plate L<\/strong>, Whited CA, Olea C Jr, Marletta MA. Determinants of<\/em>
    \n ligand affinity and heme reactivity in H-NOX domains.<\/em> Angew Chem Int Ed Engl.
    \n2010;49(4):720-3. doi:     10.1002\/anie.200904799<\/a>.<\/li>\n
  20. Carlson HK, Plate L<\/strong>, Price MS, Allen JJ, Shokat KM, Marletta MA. Use of a<\/em>
    \n semisynthetic epitope to probe histidine kinase activity and regulation.<\/em> Anal
    \nBiochem. 2010 Feb 15;397(2):139-43. doi:     10.1016\/j.ab.2009.10.009<\/a>.<\/li>\n
  21. Hassan AQ, Wang Y, Plate L<\/strong>, Stubbe J. Methodology to probe subunit<\/em>
    \n interactions in ribonucleotide reductases.<\/em> Biochemistry. 2008 Dec
    \n9;47(49):13046-55. doi:     10.1021\/bi8012559<\/a>.<\/li>\n
  22. Gianolio DA, Philbrook M, Avila LZ, Young LE, Plate L<\/strong>, Santos MR, Bernasconi
    \nR, Liu H, Ahn S, Sun W, Jarrett PK, Miller RJ. Hyaluronan-tethered opioid depots:<\/em>
    \n synthetic strategies and release kinetics in vitro and in vivo.<\/em> Bioconjug Chem.
    \n2008 Sep;19(9):1767-74. doi:     10.1021\/bc8000479<\/a>.<\/li>\n<\/ol>\n","protected":false},"excerpt":{"rendered":"

    Blackwood EA, Azizi K, Thuerauf DJ, Paxman RJ,\u00a0Plate\u00a0L, Kelly JW,\u00a0Wiseman\u00a0RL, Glembotski CC.\u00a0Pharmacologic ATF6 activation confers global protection in widespread disease models by reprograming cellular proteostasis.\u00a0Nat Commun. 2019 10(1):187. doi:\u00a010.1038\/s41467-018-08129-2 Grandjean JM,\u00a0Plate L,\u00a0Morimoto RI,\u00a0Bollong MJ,\u00a0Powers ET,\u00a0Wiseman RL.\u00a0Deconvoluting Stress-Responsive Proteostasis Signaling Pathways … Continue reading →<\/span><\/a><\/p>\n","protected":false},"author":6790,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-6","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/my.vanderbilt.edu\/plateresearch\/wp-json\/wp\/v2\/pages\/6","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/my.vanderbilt.edu\/plateresearch\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/my.vanderbilt.edu\/plateresearch\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/my.vanderbilt.edu\/plateresearch\/wp-json\/wp\/v2\/users\/6790"}],"replies":[{"embeddable":true,"href":"https:\/\/my.vanderbilt.edu\/plateresearch\/wp-json\/wp\/v2\/comments?post=6"}],"version-history":[{"count":11,"href":"https:\/\/my.vanderbilt.edu\/plateresearch\/wp-json\/wp\/v2\/pages\/6\/revisions"}],"predecessor-version":[{"id":176,"href":"https:\/\/my.vanderbilt.edu\/plateresearch\/wp-json\/wp\/v2\/pages\/6\/revisions\/176"}],"wp:attachment":[{"href":"https:\/\/my.vanderbilt.edu\/plateresearch\/wp-json\/wp\/v2\/media?parent=6"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}