Daily Archives: March 19, 2015

Identification of Extracolonic Pathologies by Computed Tomographic Colonography in Colorectal Cancer Symptomatic Patients

Posted on March 19, 2015 by Steve Halligan, Katherine Wooldrage, Edward Dadswell, Urvi Shah, Ines Kralj-Hans, Christian von Wagner, Omar Faiz, Julian Teare, Rob Edwards, Clive Kay, Guiqing Yao, Richard J. Lilford, Dion Morton, Jane Wardle, Wendy Atkin, SIGGAR Investigators

Symptoms suggestive of colorectal cancer may originate outside the colorectum. Computed tomographic colonography (CTC) is used to examine the colorectum and abdominopelvic organs simultaneously. We performed a prospective randomized controlled trial to… Continue reading →

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Nuclear Factor, Erythroid 2-Like 2 Regulates Expression of Type 3 Inositol 1,4,5-Trisphosphate Receptor and Calcium Signaling in Cholangiocytes

Posted on March 19, 2015 by Jittima Weerachayaphorn, Maria Jimena Amaya, Carlo Spirli, Piyachat Chansela, Kisha A. Mitchell-Richards, Meenakshisundaram Ananthanarayanan, Michael H. Nathanson

Most cholestatic disorders are caused by defects in cholangiocytes. The type 3 isoform of the inositol 1,4,5-trisphosphate receptor (ITPR3) is the most abundant intracellular calcium release channel in cholangiocytes. ITPR3 is required for bicarbonate … Continue reading →

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