Daily Archives: March 30, 2015

Obesity Early in Adulthood Increases Risk but Does Not Affect Outcomes of Hepatocellular Carcinoma

Posted on March 30, 2015 by Manal M. Hassan, Reham Abdel-Wahab, Ahmed Kaseb, Ahmed Shalaby, Alexandria T. Phan, Hashem B. El-Serag, Ernest Hawk, Jeff Morris, Kanwal Pratap Singh Raghav, Ju-Seog Lee, Jean-Nicolas Vauthey, Gehan Bortus, Harrys A. Torres, Christopher I. Amos, Robe

Despite the significant association between obesity and several cancers, it has been difficult to establish an association between obesity and hepatocellular carcinoma (HCC). Patients with HCC often have ascites, making it a challenge to determine body… Continue reading →

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Findings From a Randomized Controlled Trial of Fecal Transplantation for Patients With Ulcerative Colitis

Posted on March 30, 2015 by Noortje G. Rossen, Susana Fuentes, Mirjam J. van der Spek, Jan G. Tijssen, Jorn H.A. Hartman, Ann Duflou, Mark Löwenberg, Gijs R. van den Brink, Elisabeth M.H. Mathus-Vliegen, Willem M. de Vos, Erwin G. Zoetendal, Geert R. D’Haens, Cyriel Y. Ponsioen

Several case series have reported the effects of fecal microbiota transplantation (FMT) for ulcerative colitis (UC). We assessed the efficacy and safety of FMT for patients with UC in a double-blind randomized trial. Continue reading →

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Rapamycin Inhibition of mTOR Reduces Levels of the Na+/H+ Exchanger 3 in Intestines of Mice and Humans, Leading to Diarrhea

Posted on March 30, 2015 by Jun Yang, Xiaofeng Zhao, Archana Patel, Rachana Potru, Sadra Azizi-Ghannad, Michael Dolinger, James Cao, Catherine Bartholomew, Joseph Mazurkiewicz, David Conti, David Jones, Yunfei Huang, Xinjun Cindy Zhu

The immunosuppressant rapamycin frequently causes noninfectious diarrhea in organ transplant recipients. We investigated the mechanisms of this process. Continue reading →

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