Daily Archives: April 8, 2015

A Thermo-Sensitive Delivery Platform for Topical Administration of Inflammatory Bowel Disease Therapies

Posted on April 8, 2015 by Sidhartha R. Sinha, Linh P. Nguyen, Mohammed Inayathullah, Andrey Malkovskiy, Frezghi Habte, Jayakumar Rajadas, Aida Habtezion

Systemic therapies for inflammatory bowel disease are associated with an increased risk of infections and malignancies. Topical therapies reduce systemic exposure, but can be difficult to retain or have limited proximal distribution. To mitigate these … Continue reading →

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Loss of Interstitial Cells of Cajal and Patterns of Gastric Dysrhythmia in Patients With Chronic Unexplained Nausea and Vomiting

Posted on April 8, 2015 by Timothy R. Angeli, Leo K. Cheng, Peng Du, Tim Hsu-Han Wang, Cheryl E. Bernard, Maria-Giuliana Vannucchi, Maria Simonetta Faussone-Pellegrini, Christopher Lahr, Ryash Vather, John A. Windsor, Gianrico Farrugia, Thomas L. Abell, Gregory O’Grady

Chronic unexplained nausea and vomiting (CUNV) is a debilitating disease of unknown cause. Symptoms of CUNV substantially overlap with those of gastroparesis, therefore the diseases may share pathophysiologic features. We investigated this hypothesis b… Continue reading →

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Split-Dose Preparations Are Superior to Day-Before Bowel Cleansing Regimens: A Meta-analysis

Posted on April 8, 2015 by Myriam Martel, Alan N. Barkun, Charles Menard, Sophie Restellini, Omar Kherad, Alain Vanasse

There are different regimens of preparing the colon for colonoscopy, including polyethylene glycol (PEG), sodium phosphate, picosulfate, or oral sulfate solutions. We performed a meta-analysis to determine the efficacy of split-dose vs other colon prep… Continue reading →

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