Daily Archives: April 9, 2015

Weight Loss Through Lifestyle Modification Significantly Reduces Features of Nonalcoholic Steatohepatitis

Posted on April 9, 2015 by Eduardo Vilar-Gomez, Yadina Martinez-Perez, Luis Calzadilla-Bertot, Ana Torres-Gonzalez, Bienvenido Gra-Oramas, Licet Gonzalez-Fabian, Scott L. Friedman, Moises Diago, Manuel Romero-Gomez

It is not clear how weight loss affects histologic features of liver in patients with nonalcoholic steatohepatitis (NASH). We examined the association between the magnitude of weight loss through lifestyle modifications and changes in histologic featur… Continue reading →

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A Hereditary Form of Small Intestinal Carcinoid Associated With a Germline Mutation in Inositol Polyphosphate Multikinase

Posted on April 9, 2015 by Yoshitatsu Sei, Xilin Zhao, Joanne Forbes, Silke Szymczak, Qing Li, Apurva Trivedi, Mark Voellinger, Grishma Joy, Jianying Feng, Millie Whatley, MaryPat Sussex Jones, Ursula L. Harper, Stephen J. Marx, Aradhana M. Venkatesan, Settara C. Chandrasekhar

Small intestinal carcinoids are rare and difficult to diagnose and patients often present with advanced incurable disease. Although the disease occurs sporadically, there have been reports of family clusters. Hereditary small intestinal carcinoid has n… Continue reading →

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Platelet-Derived Growth Factor Receptor-α Regulates Proliferation of Gastrointestinal Stromal Tumor Cells With Mutations in by Stabilizing ETV1

Posted on April 9, 2015 by Yujiro Hayashi, Michael R. Bardsley, Yoshitaka Toyomasu, Srdjan Milosavljevic, Gabriella B. Gajdos, Kyoung Moo Choi, KMarie Reid-Lombardo, Michael L. Kendrick, Juliane Bingener-Casey, Chih-Min Tang, Jason K. Sicklick, Simon J. Gibbons, Gianrico Farru

In gastrointestinal muscles, v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog (KIT) is predominantly expressed by interstitial cells of Cajal (ICC) and platelet-derived growth factor receptor-α (PDGFRA) polypeptide is expressed by so-call… Continue reading →

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Inhibiting Inducible Nitric Oxide Synthase in Enteric Glia Restores Electrogenic Ion Transport in Mice With Colitis

Posted on April 9, 2015 by Sarah J. MacEachern, Bhavik A. Patel, Catherine M. Keenan, Michael Dicay, Kevin Chapman, Donna-Marie McCafferty, Tor C. Savidge, Paul L. Beck, Wallace K. MacNaughton, Keith A. Sharkey

Disturbances in the control of ion transport lead to epithelial barrier dysfunction in patients with colitis. Enteric glia regulate intestinal barrier function and colonic ion transport. However, it is not clear whether enteric glia are involved in epi… Continue reading →

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