Daily Archives: April 14, 2015

Hepatocyte Nicotinamide Adenine Dinucleotide Phosphate Reduced Oxidase 4 Regulates Stress Signaling, Fibrosis, and Insulin Sensitivity During Development of Steatohepatitis in Mice

Posted on April 14, 2015 by

Reactive oxidative species (ROS) are believed to be involved in the progression of nonalcoholic steatohepatitis (NASH). However, little is known about the sources of ROS in hepatocytes or their role in disease progression. We studied the effects of nic… Continue reading →

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Exclusion of T Cells From Pancreatic Carcinomas in Mice Is Regulated by Ly6C F4/80 Extratumoral Macrophages

Posted on April 14, 2015 by Gregory L. Beatty, Rafael Winograd, Rebecca A. Evans, Kristen B. Long, Santiago L. Luque, Jae W. Lee, Cynthia Clendenin, Whitney L. Gladney, Dawson M. Knoblock, Patrick D. Guirnalda, Robert H. Vonderheide

Immunotherapies that induce T-cell responses have shown efficacy against some solid malignancies in patients and mice, but these have little effect on pancreatic ductal adenocarcinoma (PDAC). We investigated whether the ability of PDAC to evade T-cell … Continue reading →

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