Daily Archives: April 24, 2015

Radiofrequency Ablation Is Associated With Decreased Neoplastic Progression in Patients With Barrett’s Esophagus and Confirmed Low-Grade Dysplasia

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Barrett’s esophagus (BE) with low-grade dysplasia (LGD) can progress to high-grade dysplasia (HGD) and esophageal adenocarcinoma (EAC). Radiofrequency ablation (RFA) has been shown to be an effective treatment for LGD in clinical trials, but its effect… Continue reading →

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Bariatric Surgery Reduces Features of Nonalcoholic Steatohepatitis in Morbidly Obese Patients

Posted on April 24, 2015 by Guillaume Lassailly, Robert Caiazzo, David Buob, Marie Pigeyre, Hélène Verkindt, Julien Labreuche, Violeta Raverdy, Emmanuelle Leteurtre, Sébastien Dharancy, Alexandre Louvet, Monique Romon, Alain Duhamel, François Pattou, Philippe Mathurin

The effects of bariatric surgery in patients with nonalcoholic fatty liver disease (NASH) are not well established. We performed a prospective study to determine the biological and clinical effects of bariatric surgery in patients with NASH. Continue reading →

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Inhibitors of ORAI1 Prevent Cytosolic Calcium-Associated Injury of Human Pancreatic Acinar Cells and Acute Pancreatitis in 3 Mouse Models

Posted on April 24, 2015 by Li Wen, Svetlana Voronina, Muhammad A. Javed, Muhammad Awais, Peter Szatmary, Diane Latawiec, Michael Chvanov, David Collier, John Barrett, Malcolm Begg, Ken Stauderman, Jack Roos, Sergey Grigoryev, Stephanie Ramos, Evan Rogers, Jeff Whitten, Gonul V

Sustained activation of the cytosolic calcium concentration induces injury to pancreatic acinar cells and necrosis. The calcium release–activated calcium modulator ORAI1 is the most abundant Ca2+ entry channel in pancreatic acinar cells; it sustains … Continue reading →

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Loss of Infliximab Into Feces Is Associated With Lack of Response to Therapy in Patients With Severe Ulcerative Colitis

Posted on April 24, 2015 by Johannan F. Brandse, Gijs R. van den Brink, Manon E. Wildenberg, Desiree van der Kleij, Theo Rispens, Jeroen M. Jansen, Ron A. Mathôt, Cyriel Y. Ponsioen, Mark Löwenberg, Geert R.A.M. D’Haens

It is not clear why some patients with ulcerative colitis (UC) do not respond to treatment with anti-tumor necrosis factor (TNF) agents, such as infliximab. It could be that some patients have high level of inflammation, with large quantities of TNF to… Continue reading →

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Interleukin 6 Increases Production of Cytokines by Colonic Innate Lymphoid Cells in Mice and Patients With Chronic Intestinal Inflammation

Posted on April 24, 2015 by Nick Powell, Jonathan W. Lo, Paolo Biancheri, Anna Vossenkämper, Eirini Pantazi, Alan W. Walker, Emilie Stolarczyk, Francesca Ammoscato, Rimma Goldberg, Paul Scott, James B. Canavan, Esperanza Perucha, Natividad Garrido-Mesa, Peter M. Irving, Jeremy

Innate lymphoid cells (ILCs) are a heterogeneous group of mucosal inflammatory cells that participate in chronic intestinal inflammation. We investigated the role of interleukin 6 (IL6) in inducing activation of ILCs in mice and in human beings with ch… Continue reading →

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