Daily Archives: May 13, 2015

Low-Cost High-Resolution Microendoscopy for the Detection of Esophageal Squamous Cell Neoplasia: An International Trial

Posted on May 13, 2015 by Marion-Anna Protano, Hong Xu, Guiqi Wang, Alexandros D. Polydorides, Sanford M. Dawsey, Junsheng Cui, Liyan Xue, Fan Zhang, Timothy Quang, Mark C. Pierce, Dongsuk Shin, Richard A. Schwarz, Manoop S. Bhutani, Michelle Lee, Neil Parikh, Chin Hur, Weira

Esophageal squamous cell neoplasia has a high mortality rate as a result of late detection. In high-risk regions such as China, screening is performed by Lugol’s chromoendoscopy (LCE). LCE has low specificity, resulting in unnecessary tissue biopsy w… Continue reading →

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Exposure to Radiocontrast Agents Induces Pancreatic Inflammation by Activation of Nuclear Factor-κB, Calcium Signaling, and Calcineurin

Posted on May 13, 2015 by Shunqian Jin, Abrahim I. Orabi, Tianming Le, Tanveer A. Javed, Swati Sah, John F. Eisses, Rita Bottino, Jeffery D. Molkentin, Sohail Z. Husain

Radiocontrast agents are required for radiographic procedures, but these agents can injure tissues by unknown mechanisms. We investigated whether exposure of pancreatic tissues to radiocontrast agents during endoscopic retrograde cholangiopancreatograp… Continue reading →

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mTORC1 Up-Regulates GP73 to Promote Proliferation and Migration of Hepatocellular Carcinoma Cells and Growth of Xenograft Tumors in Mice

Posted on May 13, 2015 by Xinxin Chen, Yanan Wang, Jun Tao, Yuzhuo Shi, Xiaochen Gai, Fuqiang Huang, Qian Ma, Zhenzhen Zhou, Hongyu Chen, Haihong Zhang, Zhibo Liu, Qian Sun, Haiyong Peng, Rongrong Chen, Yanling Jing, Huayu Yang, Yilei Mao, Hongbing Zhang

Levels of the Golgi protein 73 (GP73) increase during development of hepatocellular carcinoma (HCC); GP73 now is used as a serum marker for HCC. However, little is known about the mechanisms or effects of GP73 during hepatic carcinogenesis. Continue reading →

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Identification of a Variety of Mutations in Cancer-Predisposition Genes in Patients With Suspected Lynch Syndrome

Posted on May 13, 2015 by Matthew B. Yurgelun, Brian Allen, Rajesh R. Kaldate, Karla R. Bowles, Thaddeus Judkins, Praveen Kaushik, Benjamin B. Roa, Richard J. Wenstrup, Anne-Renee Hartman, Sapna Syngal

Multigene panels are commercially available tools for hereditary cancer risk assessment that allow for next-generation sequencing of numerous genes in parallel. However, it is not clear if these panels offer advantages over traditional genetic testing…. Continue reading →

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Delayed Gastric Emptying Is Associated With Early and Long-term Hyperglycemia in Type 1 Diabetes Mellitus

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After the Diabetes Control and Complications Trial (DCCT), the Epidemiology of Diabetes Interventions and Complications (EDIC) study continued to show persistent benefit of prior intensive therapy on neuropathy, retinopathy, and nephropathy in type 1 d… Continue reading →

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