Daily Archives: May 19, 2015

Complement Component 5 Mediates Development of Fibrosis, via Activation of Stellate Cells, in 2 Mouse Models of Chronic Pancreatitis

Posted on May 19, 2015 by Matthias Sendler, Georg Beyer, Ujjwal M. Mahajan, Vivian Kauschke, Sandrina Maertin, Claudia Schurmann, Georg Homuth, Uwe Völker, Henry Völzke, Walter Halangk, Thomas Wartmann, Frank-Ulrich Weiss, Peter Hegyi, Markus M. Lerch, Julia Mayerle

Little is known about the pathogenic mechanisms of chronic pancreatitis. We investigated the roles of complement component 5 (C5) in pancreatic fibrogenesis in mice and patients. Continue reading →

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Distinct and Synergistic Contributions of Epithelial Stress and Adaptive Immunity to Functions of Intraepithelial Killer Cells and Active Celiac Disease

Posted on May 19, 2015 by Mala Setty, Valentina Discepolo, Valérie Abadie, Sarah Kamhawi, Toufic Mayassi, Andrew Kent, Cezary Ciszewski, Maria Maglio, Emily Kistner, Govind Bhagat, Carol Semrad, Sonia S. Kupfer, Peter H. Green, Stefano Guandalini, Riccardo Troncone, Joseph A.

The mechanisms of tissue destruction during progression of celiac disease are poorly defined. It is not clear how tissue stress and adaptive immunity contribute to the activation of intraepithelial cytotoxic T cells and the development of villous atrop… Continue reading →

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