Daily Archives: May 26, 2015

Question: A 60-year-old man presented to an internal medicine physician to establish care and the initial workup revealed mildly elevated liver function tests (LFTs). CT of the abdomen was performed to evaluate the elevated LFTs and found a 4.4-cm cyst… Continue reading →

Question: A 47-year-old man was admitted to our hospital with an 8-hour history of intermittent abdominal pain that had developed suddenly. He had a history of liver cirrhosis and chronic hepatitis B virus infection for 10 years. Physical examination r… Continue reading →

Question: An 88-year-old man with a past medical history of melanoma presented for evaluation of a pancreatic tail mass found on routine imaging follow-up of a stable lung nodule (Figure A). He was asymptomatic and his physical examination revealed no … Continue reading →

The majority of individuals in Western countries will develop asymptomatic diverticulosis as they age. Diverticular disease, including diverticulitis and diverticular bleeding, affects a small minority of individuals with diverticulosis. Nonetheless, d… Continue reading →

Written as part of the Differential Diagnoses in Surgical Pathology series, this text greatly fulfills Montgomery and Greens’ hopes to “offer fresh information to trainees and help solidify fine points for more experienced pathologists [in gastroin… Continue reading →

Ahn E, Son KY, Shin DW, et al. Perceived risk as a barrier to appropriate diagnosis of irritable bowel syndrome. World J Gastroenterol 2014;20:18360–18366. Continue reading →

Crane JD, Palanivel R, Motillo EP, et al. Inhibiting peripheral serotonin synthesis reduces obesity and metabolic dysfunction by promoting brown adipose tissue thermogenesis. Nat Med 2015;21:166–172. Continue reading →

Neuroendocrine tumors represent the most frequent tumor of the small intestine. These serotonin-producing tumors arise from enterochromaffin cells of the distal small intestine, appendix, and proximal colon. They are often slow growing, which contribut… Continue reading →

Systematic approaches for assessing evidence and making recommendations (such as the GRADE system) hold the promise of improving health outcomes. For diseases with multiple clinical scenarios, recommendations on specific situations can then be weaved t… Continue reading →

We appreciate the insightful comments of Dr Chaudhury and the opportunity to extend the discussion of our study. We agree that in addition to achalasia most of the phenotypes presented by these children could be attributed to the nNOS mutation. Nitric… Continue reading →