Monthly Archives: May 2015

A Rare Cause of Esophageal Ulcers

Posted on May 27, 2015 by Masaya Iwamuro, Takao Tsuzuki, Fumio Otsuka

Question: A 64-year-old Japanese man was referred to our hospital for further investigation of a 1-month history of heartburn and epigastric pain. At presentation, the patient’s vital signs were unexceptional and he did not look seriously ill. Medica… Continue reading →

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Tail Tale: nNOS Predicts Global Defects in Esophagogastrointestinal Transit

Posted on May 27, 2015 by Arun Chaudhury

Shteyer et al reports correlative evidence of a truncating mutation of nNOSα in 2 probands (siblings) of achalasia.1 This excellent study leaves scope for additional discussion. Achalasia results from prejunctional defects of evoked nitric oxide (NO)… Continue reading →

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Exam 2: Identification of Extracolonic Pathologies by Computed Tomographic Colonography in Symptomatic Patients

Posted on May 27, 2015 by Gastroenterology
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Exam 3: Update on Fecal Microbiota Transplantation 2015: Indications, Methodologies, Mechanisms, and Outlook

Posted on May 27, 2015 by Gastroenterology
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Pouch Inflammation is Associated with a Decrease in Specific Bacterial Taxa

Posted on May 27, 2015 by Leah Reshef, Amir Kovacs, Amos Ofer, Lior Yahav, Nitsan Maharshak, Nirit keren, Fred M. Konikoff, Hagit Tulchinsky, Uri Gophna, Iris Dotan

Pouchitis is a common long-term complication in patients with ulcerative colitis (UC) undergoing proctocolectomy with ileal pouch-anal anastomosis. Since the inflammation occurs in a previously normal small bowel, studies of this process might provide … Continue reading →

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Association Between Plasma Levels of Macrophage Inhibitory Cytokine-1 Before Diagnosis of Colorectal Cancer and Mortality

Posted on May 27, 2015 by Raaj S. Mehta, Dawn Q. Chong, Mingyang Song, Jeffrey A. Meyerhardt, Kimmie Ng, Reiko Nishihara, Zhirong Qian, Teppei Morikawa, Kana Wu, Edward L. Giovannucci, Charles S. Fuchs, Shuji Ogino, Andrew T. Chan

Patients with colorectal cancer (CRC) have high circulating levels of macrophage inhibitory cytokine-1 (MIC1 or growth differentiation factor 15), a marker of inflammation that might be involved in carcinogenesis. We analyzed blood samples collected fr… Continue reading →

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High Prevalence of Nonalcoholic Fatty Liver Disease in Adolescents Undergoing Bariatric Surgery

Posted on May 27, 2015 by Stavra A. Xanthakos, Todd M. Jenkins, David E. Kleiner, Tawny W. Boyce, Reena Mourya, Rebekah Karns, Mary L. Brandt, Carroll M. Harmon, Michael A. Helmrath, Marc P. Michalsky, Anita P. Courcoulas, Meg H. Zeller, Thomas H. Inge, Teen-LABS Consortium

Little is known about the prevalence of nonalcoholic fatty liver disease (NAFLD) among severely obese adolescents or factors that determine its development. We investigated the prevalence of NAFLD in a multicenter cohort of adolescents undergoing baria… Continue reading →

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High Proportions of People With Nonceliac Wheat Sensitivity Have Autoimmune Disease or Antinuclear Antibodies

Posted on May 27, 2015 by Antonio Carroccio, Alberto D’Alcamo, Francesca Cavataio, Maurizio Soresi, Aurelio Seidita, Carmelo Sciumè, Girolamo Geraci, Giuseppe Iacono, Pasquale Mansueto

There is much interest in wheat sensitivity among people without celiac disease (CD), but little is known about any risks associated with the condition. We evaluated the prevalence of autoimmune diseases (ADs) among patients with nonceliac wheat sensit… Continue reading →

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KIT Signaling Promotes Growth of Colon Xenograft Tumors in Mice and Is Up-Regulated in a Subset of Human Colon Cancers

Posted on May 27, 2015 by Evan C. Chen, Taylor A. Karl, Tomer Kalisky, Santosh K. Gupta, Catherine A. O’Brien, Teri A. Longacre, Matt van de Rijn, Stephen R. Quake, Michael F. Clarke, Michael E. Rothenberg

Receptor tyrosine kinase (RTK) inhibitors have advanced colon cancer treatment. We investigated the role of the RTK KIT in development of human colon cancer. Continue reading →

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Congenital Anomaly Detected During Work-up of Cystic Pancreatic Lesion

Posted on May 26, 2015 by Brian Morse, Jonathan Strosberg

Question: A 60-year-old man presented to an internal medicine physician to establish care and the initial workup revealed mildly elevated liver function tests (LFTs). CT of the abdomen was performed to evaluate the elevated LFTs and found a 4.4-cm cyst… Continue reading →

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