Monthly Archives: May 2015

Identification of a Variety of Mutations in Cancer-Predisposition Genes in Patients With Suspected Lynch Syndrome

Posted on May 13, 2015 by Matthew B. Yurgelun, Brian Allen, Rajesh R. Kaldate, Karla R. Bowles, Thaddeus Judkins, Praveen Kaushik, Benjamin B. Roa, Richard J. Wenstrup, Anne-Renee Hartman, Sapna Syngal

Multigene panels are commercially available tools for hereditary cancer risk assessment that allow for next-generation sequencing of numerous genes in parallel. However, it is not clear if these panels offer advantages over traditional genetic testing…. Continue reading →

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Delayed Gastric Emptying Is Associated With Early and Long-term Hyperglycemia in Type 1 Diabetes Mellitus

Posted on May 13, 2015 by

After the Diabetes Control and Complications Trial (DCCT), the Epidemiology of Diabetes Interventions and Complications (EDIC) study continued to show persistent benefit of prior intensive therapy on neuropathy, retinopathy, and nephropathy in type 1 d… Continue reading →

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Endoscopic Suturing for Ulcer Exclusion in Patients With Massively Bleeding Large Gastric Ulcer

Posted on May 8, 2015 by Philip Wai Yan Chiu, Francis Ka Leung Chan, James Yun Wong Lau

Bleeding peptic ulcer is one of the most important causes for hospitalization worldwide. Though endoscopic hemostasis is the current standard of treatment for bleeding peptic ulcers, ulcer rebleeding remained a chief cause of mortality.1 One of the imp… Continue reading →

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Maintenance of Clonogenic KIT Human Colon Tumor Cells Requires Secretion of Stem Cell Factor by Differentiated Tumor Cells

Posted on May 8, 2015 by Szabolcs Fatrai, Susanne J. van Schelven, Inge Ubink, Klaas M. Govaert, Danielle Raats, Jan Koster, Andre Verheem, Inne H.M. Borel Rinkes, Onno Kranenburg

Colon tumors contain a fraction of undifferentiated stem cell−like cancer cells with high tumorigenic potential. Little is known about the signals that maintain these stem-like cells. We investigated whether differentiated tumor cells provide support. Continue reading →

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Prevention of Dabigatran-Related Gastrointestinal Bleeding With Gastroprotective Agents: A Population-Based Study

Posted on May 7, 2015 by Esther W. Chan, Wallis C.Y. Lau, Wai K. Leung, Michael T.C. Mok, Ying He, Teresa S.M. Tong, Ian C.K. Wong

Use of dabigatran, an inhibitor of thrombin, increases the risk of gastrointestinal bleeding (GIB). However, it is not clear whether gastroprotective agents (GPAs) prevent GIB in dabigatran users. We investigated the risk of GIB and the role of gastrop… Continue reading →

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Epidemiology, Diagnosis, and Management of Esophageal Adenocarcinoma

Posted on May 6, 2015 by Joel H. Rubenstein, Nicholas J. Shaheen

Esophageal adenocarcinoma (EAC) is rapidly increasing in incidence in Western cultures. Barrett’s esophagus is the presumed precursor lesion for this cancer. Several other risk factors for this cancer have been described, including chronic heartburn,… Continue reading →

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