Daily Archives: June 4, 2015

T Cells Engineered to Express a T-Cell Receptor Specific for Glypican-3 to Recognize and Kill Hepatoma Cells In Vitro and in Mice

Posted on June 4, 2015 by Christina Dargel, Michal Bassani-Sternberg, Julia Hasreiter, Fabio Zani, Jan-Hendrik Bockmann, Frank Thiele, Felix Bohne, Karin Wisskirchen, Susanne Wilde, Martin F. Sprinzl, Dolores J. Schendel, Angela M. Krackhardt, Wolfgang Uckert, Dirk Wohlleber,

Cancer therapies are being developed based on our ability to direct T cells against tumor antigens. Glypican-3 (GPC3) is expressed by 75% of all hepatocellular carcinomas (HCC), but not in healthy liver tissue or other organs. We aimed to generate T ce… Continue reading →

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Germline Mutations in Cause Hereditary Colorectal Cancer by Impairing DNA Repair

Posted on June 4, 2015 by Nuria Seguí, Leonardo B. Mina, Conxi Lázaro, Rebeca Sanz-Pamplona, Tirso Pons, Matilde Navarro, Fernando Bellido, Adriana López-Doriga, Rafael Valdés-Mas, Marta Pineda, Elisabet Guinó, August Vidal, José Luís Soto, Trinidad Caldés, Mercedes Durán, Mi

Identification of genes associated with hereditary cancers facilitates management of patients with family histories of cancer. We performed exome sequencing of DNA from 3 individuals from a family with colorectal cancer who met the Amsterdam criteria f… Continue reading →

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