Daily Archives: June 10, 2015

Identification of Patients With Variants in and Dose Reduction Reduces Hematologic Events During Thiopurine Treatment of Inflammatory Bowel Disease

Posted on June 10, 2015 by Marieke J.H. Coenen, Dirk J. de Jong, Corine J. van Marrewijk, Luc J.J. Derijks, Sita H. Vermeulen, Dennis R. Wong, Olaf H. Klungel, Andre L.M. Verbeek, Piet M. Hooymans, Wilbert H.M. Peters, Rene H.M. te Morsche, William G. Newman, Hans Scheffer, He

More than 20% of patients with inflammatory bowel disease (IBD) discontinue thiopurine therapy because of severe adverse drug reactions (ADRs); leukopenia is one of the most serious ADRs. Variants in the gene encoding thiopurine S-methyltransferase (TP… Continue reading →

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Accuracy of Hereditary Diffuse Gastric Cancer Testing Criteria and Outcomes in Patients With a Germline Mutation in CDH1

Posted on June 10, 2015 by Rachel S. van der Post, Ingrid P. Vogelaar, Peggy Manders, Lizet E. van der Kolk, Annemieke Cats, Liselotte P. van Hest, Rolf Sijmons, Cora M. Aalfs, Margreet G.E.M. Ausems, Encarna B. Gómez García, Anja Wagner, Frederik J. Hes, Neeltje Arts, Arjen R

Germline mutations in the cadherin 1, type 1, E-cadherin gene (CDH1) cause a predisposition to gastric cancer. We evaluated the ability of the internationally accepted hereditary diffuse gastric cancer (HDGC) criteria to identify individuals with patho… Continue reading →

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Tumor Necrosis Factor Receptor 2 Restricts the Pathogenicity of CD8 T Cells in Mice With Colitis

Posted on June 10, 2015 by Shivesh Punit, Philip E. Dubé, Cambrian Y. Liu, Nandini Girish, M. Kay Washington, D. Brent Polk

Tumor necrosis factor receptor 2 (TNFR2, Tnfrsf1b) regulates multiple aspects of immune function, but little is known about its role in the immunopathogenesis of inflammatory bowel disease (IBD). We investigated whether TNFR2 restricts the activity of … Continue reading →

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