Daily Archives: June 19, 2015

Loss of ATOH8 Increases Stem Cell Features of Hepatocellular Carcinoma Cells

Posted on June 19, 2015 by Yangyang Song, Guangjin Pan, Leilei Chen, Stephanie Ma, Tingting Zeng, Tim Hon Man Chan, Lei Li, Qizhou Lian, Raymond Chow, Xiujuan Cai, Yan Li, Yan Li, Ming Liu, Yun Li, Yinghui Zhu, Nathalie Wong, Yun-Fei Yuan, Duanqing Pei, Xin-Yuan Guan

Levels of atonal homolog 8 (ATOH8) are reduced in 48% of hepatitis B virus-associated hepatocellular carcinomas (HCCs). ATOH8 downregulation is associated with loss of tumor differentiation, indicating an effect mediated by cancer stem cells. We invest… Continue reading →

Posted in News | Comments Off on Loss of ATOH8 Increases Stem Cell Features of Hepatocellular Carcinoma Cells

The genetic landscape and biomarkers of hepatocellular carcinoma

Posted on June 19, 2015 by Jessica Zucman-Rossi, Augusto Villanueva, Jean-Charles Nault, Josep M. Llovet

Hepatocellular carcinoma (HCC) has emerged as a major cause of cancer-related death. Its mortality has increased in Western populations, with a minority of patients diagnosed at early stages, when curative treatments are feasible. Only the multikinase … Continue reading →

Posted in News | Comments Off on The genetic landscape and biomarkers of hepatocellular carcinoma

Fat-Specific Protein 27/CIDEC Promotes Development of Alcoholic Steatohepatitis in Mice and Humans

Posted on June 19, 2015 by Ming-Jiang Xu, Yan Cai, Hua Wang, José Altamirano, Binxia Chang, Adeline Bertola, Gemma Odena, Jim Lu, Naoki Tanaka, Kimihiko Matsusue, Tsutomu Matsubara, Partha Mukhopadhyay, Shioko Kimura, Pal Pacher, Frank J. Gonzalez, Ramon Bataller, Bin Gao

Alcoholic steatohepatitis (ASH) is the progressive form of alcoholic liver disease and may lead to cirrhosis and hepatocellular carcinoma. We studied mouse models and human tissues to identify molecules associated with ASH progression and focused on th… Continue reading →

Posted in News | Comments Off on Fat-Specific Protein 27/CIDEC Promotes Development of Alcoholic Steatohepatitis in Mice and Humans