Daily Archives: June 24, 2015

Patients with bi-allelic germline mutations in mismatch repair (MMR) genes (MLH1, MSH2, MSH6, or PMS2) develop a rare but severe variant of Lynch syndrome called constitutional MMR deficiency (CMMRD). This syndrome is characterized by early-onset color… Continue reading →

Patients with perianal fistulizing Crohn’s disease have a poor prognosis because these lesions do not heal well. We evaluated the effects of local administration of bone marrow-derived mesenchymal stromal cells (MSCs) to these patients from healthy d… Continue reading →

Overweight and obesity undoubtedly drive the prevalence of nonalcoholic fatty liver disease (NAFLD) in the population, promoting liver fat accumulation. There is also evidence that obesity may increase disease progression to nonalcoholic steatohepatiti… Continue reading →

Nonalcoholic fatty liver disease (NAFLD) is one of the most common causes of chronic liver disease in the United States.1–3 It has been broadly subdivided into 2 categories including nonalcoholic fatty liver, which is considered to be the milder phen… Continue reading →

The adenoma detection rate (ADR) has become a validated quality indicator of colonoscopy; the higher the ADR of colonoscopists, the lower the risk of interval colorectal cancer (CRC) and the lower the risk of dying from CRC.1,2 Not surprisingly, this f… Continue reading →

Persons who consume >25 g of alcohol a day are at risk of developing hepatic steatosis, alcoholic hepatitis, and cirrhosis. Alcoholic cirrhosis is the eighth most common cause of mortality in the United States and the second highest cause of mortality among all gastrointestinal diseases.1 Although women are at greater risk for alcohol-related liver disease for any given level of alcohol consumption, overall morbidity and mortality is greater in men, likely owing to their higher levels of total alcohol consumption. Continue reading →

Over the past 2 decades, multiple studies have reported low-grade inflammation in the mucosal biopsies of irritable bowel syndrome (IBS) and postinfectious (PI)-IBS patients. The increases in the inflammatory mediators were modest, variable and often i… Continue reading →

Over the past 10 years, the “Clinical Challenges and Images in GI” section of Gastroenterology has consistently received high marks from the readership because of its diversity of novel cases with associated images. The journal receives >30 submissions each month from around the world. We select 4 cases for publication in each issue of the journal as well 6 cases that are published exclusively on line. Continue reading →

The American Gastroenterological Association (AGA) journals Gastroenterology, Clinical Gastroenterology and Hepatology, and Cellular and Molecular Gastroenterology and Hepatology strive to stay on the cutting edge of the latest digital publishing techn… Continue reading →

Complete eradication of Barrett’s esophagus (BE) often requires multiple sessions of radiofrequency ablation (RFA). Little is known about the effects of case volume on the safety and efficacy of RFA or about the presence or contour of learning curves… Continue reading →