MicroRNA214 Is Associated With Progression of Ulcerative Colitis, and Inhibition Reduces Development of Colitis and Colitis-Associated Cancer in Mice

Posted on June 5, 2015 by Christos Polytarchou, Daniel W. Hommes, Tiziana Palumbo, Maria Hatziapostolou, Marina Koutsioumpa, Georgios Koukos, Andrea E. van der Meulen-de Jong, Angelos Oikonomopoulos, Welmoed K. van Deen, Christina Vorvis, Oksana B. Serebrennikova, Eleni Birli

Persistent activation of the inflammatory response contributes to the development of inflammatory bowel diseases, which increase the risk of colorectal cancer. We aimed to identify microRNAs that regulate inflammation during the development of ulcerative colitis (UC) and progression to colitis-associated colon cancer (CAC).

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