Monthly Archives: June 2015

Physician Non-adherence to Colonoscopy Interval Guidelines in the Veterans Affairs Healthcare System

Colonoscopy can decrease colorectal cancer (CRC) mortality, although performing this procedure more frequently than recommended could increase costs and risks to patients. We aimed to determine rates and correlates of physician non-adherence to guideli… Continue reading

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Exome Sequencing Reveals Germline Mutation that Reduces PTEN Expression and is Associated with Hamartomatous Polyposis and Gastrointestinal Ganglioneuromas

Hamartomatous polyposis syndromes (HPS) account for a small but appreciable proportion of inherited gastrointestinal cancer predisposition syndromes; patients with HPS have an increased risk for colon and extracolonic malignancies. We present a unique … Continue reading

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A Rare Cause of Abdominal Pain by Pancreatic Mass in a Young Female Patient

Question: A 24-year-old woman presented with epigastric pain which began about 2 years ago and progressively worsened over the past 6 months. The pain occurred intermittently but usually began after a meal, lasted for about 1 hour, and radiated to the… Continue reading

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Covering the Cover

The treatment of severe acute pancreatitis remains largely supportive because pharmacotherapy that affects the clinical course has yet to be realized. The consequences of severe acute pancreatitis that contributes to increase morbidity and mortality in… Continue reading

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A Spiraling Case of Persistent Dysphagia

Question: A 77-year-old woman with gastroesophageal reflux disease, hypertension, and recurrent aspiration pneumonias presented as a referral for evaluation and management of persistent dysphagia. She reported having dysphagia to liquids more than soli… Continue reading

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An Unusual Case of Abdominal Pain and Diarrhea

Question: A 46-year-old woman with a background of primary hyperparathyroidism was referred by her endocrinologist for colonoscopy for a 5-month history of diarrhea and right-sided abdominal pain. She reported sudden onset of abdominal pain with watery… Continue reading

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An Intriguing Case of Bright Red Blood per Rectum

Question: A 36-year-old man with a history of seizure disorder, mental retardation, and recurrent aspiration requiring percutaneous endoscopic gastrojejunostomy tube for feedings, presented to the emergency room with bright red blood per rectum. He was… Continue reading

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A Rare Gastric Tumor in a Young Woman

Question: A 26-year-old woman was admitted with a 3-week history of progressive abdominal distension, nausea, vomiting, and tarry stool. She denied any significant past medical history or family history. Physical examination revealed mild epigastric te… Continue reading

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Pancreatic Duct Dilatation in Elderly Patient With Abdominal Pain

Question: An 87-year-old woman with history of dementia, atrial fibrillation, hypertension, and gastroesophageal reflux disease presented with abdominal pain. CT demonstrated abnormal location of a portion of the pancreas (Figure A–D, arrowheads) and… Continue reading

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Diagnosis of Constitutional Mismatch Repair-deficiency Syndrome Based on Microsatellite Instability and Lymphocyte Tolerance to Methylating Agents

Patients with bi-allelic germline mutations in mismatch repair (MMR) genes (MLH1, MSH2, MSH6, or PMS2) develop a rare but severe variant of Lynch syndrome called constitutional MMR deficiency (CMMRD). This syndrome is characterized by early-onset color… Continue reading

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