Monthly Archives: June 2015
Allogeneic Bone Marrow-derived Mesenchymal Stromal Cells Promote Healing of Refractory Perianal Fistulas in Patients with Crohn’s Disease
Patients with perianal fistulizing Crohn’s disease have a poor prognosis because these lesions do not heal well. We evaluated the effects of local administration of bone marrow-derived mesenchymal stromal cells (MSCs) to these patients from healthy d… Continue reading
Weight Loss for a Healthy Liver
Overweight and obesity undoubtedly drive the prevalence of nonalcoholic fatty liver disease (NAFLD) in the population, promoting liver fat accumulation. There is also evidence that obesity may increase disease progression to nonalcoholic steatohepatiti… Continue reading
The Hierarchical Model of NAFLD: Prognostic Significance of Histologic Features in NASH
Nonalcoholic fatty liver disease (NAFLD) is one of the most common causes of chronic liver disease in the United States.1–3 It has been broadly subdivided into 2 categories including nonalcoholic fatty liver, which is considered to be the milder phen… Continue reading
Adenoma Detection Race at Colonoscopy: The Good and the Bad
The adenoma detection rate (ADR) has become a validated quality indicator of colonoscopy; the higher the ADR of colonoscopists, the lower the risk of interval colorectal cancer (CRC) and the lower the risk of dying from CRC.1,2 Not surprisingly, this f… Continue reading
MELDing the Lille Score to More Accurately Predict Mortality in Alcoholic Hepatitis
Persons who consume >25 g of alcohol a day are at risk of developing hepatic steatosis, alcoholic hepatitis, and cirrhosis. Alcoholic cirrhosis is the eighth most common cause of mortality in the United States and the second highest cause of mortality among all gastrointestinal diseases.1 Although women are at greater risk for alcohol-related liver disease for any given level of alcohol consumption, overall morbidity and mortality is greater in men, likely owing to their higher levels of total alcohol consumption. Continue reading
Symptom Generation by Mucosal Inflammation in Irritable Bowel Syndrome
Over the past 2 decades, multiple studies have reported low-grade inflammation in the mucosal biopsies of irritable bowel syndrome (IBS) and postinfectious (PI)-IBS patients. The increases in the inflammatory mediators were modest, variable and often i… Continue reading
Practical Teaching Cases: A New Section for Trainees and Young GIs
Over the past 10 years, the “Clinical Challenges and Images in GI” section of Gastroenterology has consistently received high marks from the readership because of its diversity of novel cases with associated images. The journal receives >30 submissions each month from around the world. We select 4 cases for publication in each issue of the journal as well 6 cases that are published exclusively on line. Continue reading
Helping Authors Organize Their Research: ORCID in the AGA Journals
The American Gastroenterological Association (AGA) journals Gastroenterology, Clinical Gastroenterology and Hepatology, and Cellular and Molecular Gastroenterology and Hepatology strive to stay on the cutting edge of the latest digital publishing techn… Continue reading
Effects of the Learning Curve on Efficacy of Radiofrequency Ablation for Barrett’s Esophagus
Complete eradication of Barrett’s esophagus (BE) often requires multiple sessions of radiofrequency ablation (RFA). Little is known about the effects of case volume on the safety and efficacy of RFA or about the presence or contour of learning curves… Continue reading
Amitriptyline for Functional Dyspepsia: Importance of Symptom Profile and Making a Case for Gastric Emptying Testing
Functional dyspepsia, a prevalent disorder with chronic upper abdominal symptoms, is a management challenge, particularly among patients referred to tertiary centers. The literature is dominated by investigations into acid suppressant or Helicobacter p… Continue reading