Monthly Archives: June 2015

New Genetic and Genomic Approaches in the Post-GWAS Era – Back to the Future

Posted on June 11, 2015 by Joanne Ngeow, Charis Eng

The identification of all human genes and their regulatory regions provides the essential framework for our understanding of the molecular basis of disease. There is a lot of enthusiasm for applying next-generation sequencing methods towards achieving … Continue reading →

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Identification of Patients With Variants in and Dose Reduction Reduces Hematologic Events During Thiopurine Treatment of Inflammatory Bowel Disease

Posted on June 10, 2015 by Marieke J.H. Coenen, Dirk J. de Jong, Corine J. van Marrewijk, Luc J.J. Derijks, Sita H. Vermeulen, Dennis R. Wong, Olaf H. Klungel, Andre L.M. Verbeek, Piet M. Hooymans, Wilbert H.M. Peters, Rene H.M. te Morsche, William G. Newman, Hans Scheffer, He

More than 20% of patients with inflammatory bowel disease (IBD) discontinue thiopurine therapy because of severe adverse drug reactions (ADRs); leukopenia is one of the most serious ADRs. Variants in the gene encoding thiopurine S-methyltransferase (TP… Continue reading →

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Accuracy of Hereditary Diffuse Gastric Cancer Testing Criteria and Outcomes in Patients With a Germline Mutation in CDH1

Posted on June 10, 2015 by Rachel S. van der Post, Ingrid P. Vogelaar, Peggy Manders, Lizet E. van der Kolk, Annemieke Cats, Liselotte P. van Hest, Rolf Sijmons, Cora M. Aalfs, Margreet G.E.M. Ausems, Encarna B. Gómez García, Anja Wagner, Frederik J. Hes, Neeltje Arts, Arjen R

Germline mutations in the cadherin 1, type 1, E-cadherin gene (CDH1) cause a predisposition to gastric cancer. We evaluated the ability of the internationally accepted hereditary diffuse gastric cancer (HDGC) criteria to identify individuals with patho… Continue reading →

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Tumor Necrosis Factor Receptor 2 Restricts the Pathogenicity of CD8 T Cells in Mice With Colitis

Posted on June 10, 2015 by Shivesh Punit, Philip E. Dubé, Cambrian Y. Liu, Nandini Girish, M. Kay Washington, D. Brent Polk

Tumor necrosis factor receptor 2 (TNFR2, Tnfrsf1b) regulates multiple aspects of immune function, but little is known about its role in the immunopathogenesis of inflammatory bowel disease (IBD). We investigated whether TNFR2 restricts the activity of … Continue reading →

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Interleukin-8 Induces Expression of FOXC1 to Promote Transactivation of and in Hepatocellular Carcinoma Cell Lines and Formation of Metastases in Mice

Posted on June 8, 2015 by Wenjie Huang, Zhangqian Chen, Lin Zhang, Dean Tian, Daowen Wang, Daiming Fan, Kaichun Wu, Limin Xia

Inflammation regulated by interleukin (IL) 8 promotes metastasis of hepatocellular carcinoma (HCC). The transcription factor forkhead box C1 (FOXC1) promotes metastasis by activating the epithelial to mesenchymal transition; its levels in liver tumors … Continue reading →

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Endoscopic Submucosal Dissection Using Head-mounted Display

Posted on June 5, 2015 by Toshiyuki Morisawa, Hajime Kida, Fusako Kusumi, Satoshi Okinaga, Masaya Ohana

Endoscopic submucosal dissection (ESD) is an expert endoscopic technique for en bloc resection of mucosal cancers in the esophagus, stomach, and colon.1–3 During the procedure, the ESD operator must concentrate on the endoscopy monitor to avoid compl… Continue reading →

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MicroRNA214 Is Associated With Progression of Ulcerative Colitis, and Inhibition Reduces Development of Colitis and Colitis-Associated Cancer in Mice

Posted on June 5, 2015 by Christos Polytarchou, Daniel W. Hommes, Tiziana Palumbo, Maria Hatziapostolou, Marina Koutsioumpa, Georgios Koukos, Andrea E. van der Meulen-de Jong, Angelos Oikonomopoulos, Welmoed K. van Deen, Christina Vorvis, Oksana B. Serebrennikova, Eleni Birli

Persistent activation of the inflammatory response contributes to the development of inflammatory bowel diseases, which increase the risk of colorectal cancer. We aimed to identify microRNAs that regulate inflammation during the development of ulcerati… Continue reading →

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Postoperative Mortality Among Patients With Inflammatory Bowel Diseases: A Systematic Review and Meta-Analysis of Population-Based Studies

Posted on June 5, 2015 by Sunny Singh, Ahmed Al-Darmaki, Alexandra D. Frolkis, Cynthia H. Seow, Yvette Leung, Kerri L. Novak, Subrata Ghosh, Bertus Eksteen, Remo Panaccione, Gilaad G. Kaplan

There have been varying reports of mortality after intestinal resection for the inflammatory bowel diseases (IBDs). We performed a systematic review and meta-analysis of population-based studies to determine postoperative mortality after intestinal res… Continue reading →

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T Cells Engineered to Express a T-Cell Receptor Specific for Glypican-3 to Recognize and Kill Hepatoma Cells In Vitro and in Mice

Posted on June 4, 2015 by Christina Dargel, Michal Bassani-Sternberg, Julia Hasreiter, Fabio Zani, Jan-Hendrik Bockmann, Frank Thiele, Felix Bohne, Karin Wisskirchen, Susanne Wilde, Martin F. Sprinzl, Dolores J. Schendel, Angela M. Krackhardt, Wolfgang Uckert, Dirk Wohlleber,

Cancer therapies are being developed based on our ability to direct T cells against tumor antigens. Glypican-3 (GPC3) is expressed by 75% of all hepatocellular carcinomas (HCC), but not in healthy liver tissue or other organs. We aimed to generate T ce… Continue reading →

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Germline Mutations in Cause Hereditary Colorectal Cancer by Impairing DNA Repair

Posted on June 4, 2015 by Nuria Seguí, Leonardo B. Mina, Conxi Lázaro, Rebeca Sanz-Pamplona, Tirso Pons, Matilde Navarro, Fernando Bellido, Adriana López-Doriga, Rafael Valdés-Mas, Marta Pineda, Elisabet Guinó, August Vidal, José Luís Soto, Trinidad Caldés, Mercedes Durán, Mi

Identification of genes associated with hereditary cancers facilitates management of patients with family histories of cancer. We performed exome sequencing of DNA from 3 individuals from a family with colorectal cancer who met the Amsterdam criteria f… Continue reading →

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