Daily Archives: July 10, 2015

Efficacy and Safety of Ombitasvir, Paritaprevir, and Ritonavir in an Open-label Study of Patients With Genotype 1b Chronic Hepatitis C Virus, With and Without Cirrhosis

Posted on July 10, 2015 by Eric Lawitz, Mihály Makara, Ulus Salih Akarca, Paul J. Thuluvath, Liliana Lucia Preotescu, Peter Varunok, Rosa Mª. Morillas, Coleen Hall, Niloufar Mobashery, Rebecca Redman, Tami Pilot-Matias, Regis A. Vilchez, Christophe Hézode

& Aims: Interferon-free treatment options are rapidly evolving for patients with chronic hepatitis C virus (HCV) genotype 1b (GT1b) infection with cirrhosis and for nonresponders to prior pegylated interferon and ribavirin therapy. We performed a phase 2b, open-label trial of the combination of ombitasvir (a NS5A replication complex inhibitor), paritaprevir, and ritonavir (an NS3/4A protease inhibitor)—an interferon- and ribavirin-free regimen—in difficult-to-treat patients, including prior null responders and patients with cirrhosis. Continue reading →

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Proteolytic Cleavage and Loss of Function of Biologic Agents that Neutralize Tumor Necrosis Factor in the Mucosa of Patients with Inflammatory Bowel Disease

Posted on July 10, 2015 by Paolo Biancheri, Randall J. Brezski, Antonio Di Sabatino, Allison R. Greenplate, Keri L. Soring, Gino R. Corazza, Klaartje B. Kok, Laura Rovedatti, Anna Vossenkämper, Nadja Ahmad, Susanne A. Snoek, Severine Vermeire, Paul Rutgeerts, Robert E. Jordan,

Many patients with inflammatory bowel disease (IBD) fail to respond to anti-tumor necrosis factor (TNF) agents such as infliximab and adalimumab, and etanercept is not effective in treatment of Crohn’s disease. Activated matrix metalloproteinase 3 (M… Continue reading →

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SOX9 Maintains Reserve Stem Cells and Preserves Radio-resistance in Mouse Small Intestine

Posted on July 10, 2015 by Kyle C. Roche, Adam D. Gracz, Xiao Fu Liu, Victoria Newton, Haruhiko Akiyama, Scott T. Magness

Reserve intestinal stem cells (rISCs) mediate epithelial regeneration following tissue damage. Unlike active intestinal stem cells (aISCs), rISCs slowly cycle under homeostatic conditions, allowing for their identification with label retention assays. … Continue reading →

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Role of Autophagy in the Maintenance of Intestinal Homeostasis

Posted on July 10, 2015 by Leigh A. Baxt, Ramnik J. Xavier

Genome-wide association studies of inflammatory bowel disease have identified several risk loci in genes that regulate autophagy, and studies have provided insight into the functional effects of these polymorphisms. We review the mechanisms by which au… Continue reading →

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