Monthly Archives: July 2015

Park EC, Kim SI, Hong Y, et al. Inhibition of Cyp4A reduces hepatic endoplasmic reticulum stress and features of diabetes in mice. Gastroenterology 2014; 147:860–869. Continue reading →

& Aims: Interferon-free treatment options are rapidly evolving for patients with chronic hepatitis C virus (HCV) genotype 1b (GT1b) infection with cirrhosis and for nonresponders to prior pegylated interferon and ribavirin therapy. We performed a phase 2b, open-label trial of the combination of ombitasvir (a NS5A replication complex inhibitor), paritaprevir, and ritonavir (an NS3/4A protease inhibitor)—an interferon- and ribavirin-free regimen—in difficult-to-treat patients, including prior null responders and patients with cirrhosis. Continue reading →

Many patients with inflammatory bowel disease (IBD) fail to respond to anti-tumor necrosis factor (TNF) agents such as infliximab and adalimumab, and etanercept is not effective in treatment of Crohn’s disease. Activated matrix metalloproteinase 3 (M… Continue reading →

Reserve intestinal stem cells (rISCs) mediate epithelial regeneration following tissue damage. Unlike active intestinal stem cells (aISCs), rISCs slowly cycle under homeostatic conditions, allowing for their identification with label retention assays. … Continue reading →

Genome-wide association studies of inflammatory bowel disease have identified several risk loci in genes that regulate autophagy, and studies have provided insight into the functional effects of these polymorphisms. We review the mechanisms by which au… Continue reading →

Recent observations suggest that subjective measures of disease activity in inflammatory bowel disease (IBD) are often misleading. Objective measures of inflammation are more closely associated with important long-term outcomes, but often depend upon i… Continue reading →

Interventional endoscopic ultrasonography (EUS) including EUS-guided fine needle aspiration (FNA), biliary drainage (BD), and pseudocyst drainage (PD) has recently been widely performed.1 However, if stenosis of the esophagus is present, it may be chal… Continue reading →

We conducted an open-label crossover trial to test whether proton pump inhibitors (PPIs) affect the gastrointestinal microbiome to facilitate Clostridium difficile infection (CDI). Twelve healthy volunteers each donated 2 baseline fecal samples, 4 week… Continue reading →

The discovery of hepcidin in 2000 and the subsequent unprecedented explosion of research and discoveries in the iron field have dramatically changed our understanding of human disorders of iron metabolism. Today, hereditary hemochromatosis, the paradig… Continue reading →

Withdrawal times and adenoma detection rates are widely used quality indicators for screening colonoscopy. More rapid withdrawal times have been associated with undetected adenomas, which can increase risk for interval colorectal cancer. Continue reading →