Daily Archives: August 3, 2015

Efficacy of Sofosbuvir Plus Ribavirin With or Without Peginterferon-alfa in Patients With HCV Genotype 3 Infection and Treatment-Experienced Patients with Cirrhosis and HCV Genotype 2 Infection

Posted on August 3, 2015 by Graham R. Foster, Stephen Pianko, Ashley Brown, Daniel Forton, Ronald G. Nahass, Jacob George, Eleanor Barnes, Diana M. Brainard, Benedetta Massetto, Ming Lin, Bin Han, John G. McHutchison, G. Mani Subramanian, Curtis Cooper, Kosh Agarwal, BOSON Stud

We performed an open-label, randomized, phase 3 trial to determine the efficacy and safety of sofosbuvir plus ribavirin, with and without peginterferon-alfa, in treatment-experienced patients with cirrhosis and hepatitis C virus (HCV) genotype 2 infect… Continue reading →

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Efficacy of Sofosbuvir Plus Ribavirin With or Without Peginterferon-alfa in Patients With HCV Genotype 3 Infection and Treatment-Experienced Patients with Cirrhosis and HCV Genotype 2 Infection

Posted on August 3, 2015 by Graham R. Foster, Stephen Pianko, Ashley Brown, Daniel Forton, Ronald G. Nahass, Jacob George, Eleanor Barnes, Diana M. Brainard, Benedetta Massetto, Ming Lin, Bin Han, John G. McHutchison, G. Mani Subramanian, Curtis Cooper, Kosh Agarwal, BOSON Stud

We performed an open-label, randomized, phase 3 trial to determine the efficacy and safety of sofosbuvir plus ribavirin, with and without peginterferon-alfa, in treatment-experienced patients with cirrhosis and hepatitis C virus (HCV) genotype 2 infect… Continue reading →

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MicroRNA-124 Reduces Pentose Phosphate Pathway and Proliferation by Targeting and mRNAs in Human Colorectal Cancer Cells

Posted on August 3, 2015 by Zhaoping Qiu, Weijie Guo, Qifeng Wang, Zhiao Chen, Shenglin Huang, Fangyu Zhao, Ming Yao, Yingjun Zhao, Xianghuo He

Cancer cells alter glucose metabolism to support their uncontrolled proliferation. Changes in microRNAs (miRNAs) have been associated with colorectal cancer (CRC) development and progression, but it is not clear whether they regulate metabolism in CRC … Continue reading →

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MicroRNA-124 Reduces Pentose Phosphate Pathway and Proliferation by Targeting and mRNAs in Human Colorectal Cancer Cells

Posted on August 3, 2015 by Zhaoping Qiu, Weijie Guo, Qifeng Wang, Zhiao Chen, Shenglin Huang, Fangyu Zhao, Ming Yao, Yingjun Zhao, Xianghuo He

Cancer cells alter glucose metabolism to support their uncontrolled proliferation. Changes in microRNAs (miRNAs) have been associated with colorectal cancer (CRC) development and progression, but it is not clear whether they regulate metabolism in CRC … Continue reading →

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Mutation spectrum and risk of colorectal cancer in African American families with Lynch Syndrome

Posted on August 3, 2015 by Rodrigo Santa Cruz Guindalini, Aung Ko Win, Cassandra Gulden, Noralane M. Lindor, Polly A. Newcomb, Robert W. Haile, Victoria Raymond, Elena Stoffel, Michael Hall, Xavier Llor, Chinedu I. Ukaegbu, Ilana Solomon, Jeffrey Weitzel, Matthew Kalady, Amie

African Americans (AAs) have the highest incidence and mortality of colorectal cancer (CRC) in the United States (US). Few data are available on genetic and non-genetic risk factors for CRC among AAs. Little is known about cancer risks and mutations in… Continue reading →

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Mutation spectrum and risk of colorectal cancer in African American families with Lynch Syndrome

Posted on August 3, 2015 by Rodrigo Santa Cruz Guindalini, Aung Ko Win, Cassandra Gulden, Noralane M. Lindor, Polly A. Newcomb, Robert W. Haile, Victoria Raymond, Elena Stoffel, Michael Hall, Xavier Llor, Chinedu I. Ukaegbu, Ilana Solomon, Jeffrey Weitzel, Matthew Kalady, Amie

African Americans (AAs) have the highest incidence and mortality of colorectal cancer (CRC) in the United States (US). Few data are available on genetic and non-genetic risk factors for CRC among AAs. Little is known about cancer risks and mutations in… Continue reading →

Posted in News | Comments Off on Mutation spectrum and risk of colorectal cancer in African American families with Lynch Syndrome

Analysis of Dysplasia in Patients with Barrett’s Esophagus Based on Expression Pattern of 90 Genes

Posted on August 3, 2015 by Sibu Varghese, Richard Newton, Caryn S. Ross-Innes, Pierre Lao-Sirieix, Kausilia K. Krishnadath, Maria O’Donovan, M. Novelli, Lorenz Wernisch, Jacques Bergman, Rebecca C. Fitzgerald

Diagnoses of dysplasia, based on histologic analyses, dictate management decisions for patients with Barrett’s esophagus (BE). However, there is much intra- and inter-observer variation in identification of dysplasia—particularly low-grade dysplasia … Continue reading →

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Analysis of Dysplasia in Patients with Barrett’s Esophagus Based on Expression Pattern of 90 Genes

Posted on August 3, 2015 by Sibu Varghese, Richard Newton, Caryn S. Ross-Innes, Pierre Lao-Sirieix, Kausilia K. Krishnadath, Maria O’Donovan, M. Novelli, Lorenz Wernisch, Jacques Bergman, Rebecca C. Fitzgerald

Diagnoses of dysplasia, based on histologic analyses, dictate management decisions for patients with Barrett’s esophagus (BE). However, there is much intra- and inter-observer variation in identification of dysplasia—particularly low-grade dysplasia … Continue reading →

Posted in News | Comments Off on Analysis of Dysplasia in Patients with Barrett’s Esophagus Based on Expression Pattern of 90 Genes