Monthly Archives: August 2015
Efficacy of Ledipasvir and Sofosbuvir, With or Without Ribavirin, for 12 Weeks in Patients With HCV Genotype 3 or 6 Infection
We performed a phase 2 clinical trial to evaluate the efficacy and safety of ledipasvir and sofosbuvir, with or without ribavirin, in patients infected with HCV genotype 3 or 6. Continue reading
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Prostaglandin E Promotes Colorectal Cancer Stem Cell Expansion and Metastasis in Mice
Inflammation may contribute to formation, maintenance, and expansion of cancer stem cells (CSCs), which have the capacity for self-renewal, differentiation, and resistance to cytotoxic agents. We investigated the effects of the inflammatory mediator pr… Continue reading
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Prostaglandin E Promotes Colorectal Cancer Stem Cell Expansion and Metastasis in Mice
Inflammation may contribute to formation, maintenance, and expansion of cancer stem cells (CSCs), which have the capacity for self-renewal, differentiation, and resistance to cytotoxic agents. We investigated the effects of the inflammatory mediator pr… Continue reading
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STAT3 Mediated Remodeling of the Tumor Microenvironment Results in Enhanced Tumor Drug Delivery in a Mouse Model of Pancreatic Cancer
STAT3 inhibition combined with gemcitabine remodels the tumor stroma to enhance tumor drug delivery and improve survival in a genetic mouse model of pancreatic cancer. Continue reading
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STAT3 Mediated Remodeling of the Tumor Microenvironment Results in Enhanced Tumor Drug Delivery in a Mouse Model of Pancreatic Cancer
STAT3 inhibition combined with gemcitabine remodels the tumor stroma to enhance tumor drug delivery and improve survival in a genetic mouse model of pancreatic cancer. Continue reading
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Increased Risk of Functional Gastrointestinal Sequelae Following infection among Active Duty United States Military Personnel (1998-2010)
Some acute enteric infections are associated with development of functional gastrointestinal disorders, most commonly irritable bowel syndrome, but also other functional and organic gastrointestinal sequelae. Clostridium difficile infection has increas… Continue reading
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Increased Risk of Functional Gastrointestinal Sequelae Following infection among Active Duty United States Military Personnel (1998-2010)
Some acute enteric infections are associated with development of functional gastrointestinal disorders, most commonly irritable bowel syndrome, but also other functional and organic gastrointestinal sequelae. Clostridium difficile infection has increas… Continue reading
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Genetics of Inflammatory Bowel Diseases
In this Review, we provide an update on genome-wide association studies (GWAS) in inflammatory bowel disease (IBD). In addition, we summarize progress in defining the functional consequences of associated alleles for coding and non-coding genetic varia… Continue reading
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Genetics of Inflammatory Bowel Diseases
In this Review, we provide an update on genome-wide association studies (GWAS) in inflammatory bowel disease (IBD). In addition, we summarize progress in defining the functional consequences of associated alleles for coding and non-coding genetic varia… Continue reading
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Diet low in FODMAPs Reduces Symptoms of Irritable Bowel Syndrome as Well as Traditional Dietary Advice: A Randomized Controlled Trial
A diet with reduced content of fermentable short chain carbohydrates (fermentable oligo-, di-, monosaccharides and polyols, FODMAPs) has been reported to be effective in the treatment of patients with irritable bowel syndrome (IBS). However, there is n… Continue reading
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