Monthly Archives: August 2015
Personalizing Colonoscopy Screening for Elderly Individuals Based on Screening History, Cancer Risk, and Comorbidity Status Could Increase Cost Effectiveness
Colorectal cancer (CRC) screening decisions for elderly individuals are often made based primarily on age—other factors that affect the effectiveness and cost effectiveness of screening are often not considered. We investigated the relative importanc… Continue reading
Extreme Bradycardia After First Doses of Sofosbuvir and Daclatasvir in Patients Receiving Amiodarone: 2 Cases Including a Rechallenge
Sofosbuvir and daclatasvir are direct-acting antiviral drugs used to treat chronic hepatitis C virus infection. In 2015, the Food and Drug Administration and European Medical Agency warned that bradycardia could occur when amiodarone was administered i… Continue reading
Extreme Bradycardia After First Doses of Sofosbuvir and Daclatasvir in Patients Receiving Amiodarone: 2 Cases Including a Rechallenge
Sofosbuvir and daclatasvir are direct-acting antiviral drugs used to treat chronic hepatitis C virus infection. In 2015, the Food and Drug Administration and European Medical Agency warned that bradycardia could occur when amiodarone was administered i… Continue reading
Efficacy of Sofosbuvir Plus Ribavirin With or Without Peginterferon-alfa in Patients With HCV Genotype 3 Infection and Treatment-Experienced Patients with Cirrhosis and HCV Genotype 2 Infection
We performed an open-label, randomized, phase 3 trial to determine the efficacy and safety of sofosbuvir plus ribavirin, with and without peginterferon-alfa, in treatment-experienced patients with cirrhosis and hepatitis C virus (HCV) genotype 2 infect… Continue reading
Efficacy of Sofosbuvir Plus Ribavirin With or Without Peginterferon-alfa in Patients With HCV Genotype 3 Infection and Treatment-Experienced Patients with Cirrhosis and HCV Genotype 2 Infection
We performed an open-label, randomized, phase 3 trial to determine the efficacy and safety of sofosbuvir plus ribavirin, with and without peginterferon-alfa, in treatment-experienced patients with cirrhosis and hepatitis C virus (HCV) genotype 2 infect… Continue reading
MicroRNA-124 Reduces Pentose Phosphate Pathway and Proliferation by Targeting and mRNAs in Human Colorectal Cancer Cells
Cancer cells alter glucose metabolism to support their uncontrolled proliferation. Changes in microRNAs (miRNAs) have been associated with colorectal cancer (CRC) development and progression, but it is not clear whether they regulate metabolism in CRC … Continue reading
MicroRNA-124 Reduces Pentose Phosphate Pathway and Proliferation by Targeting and mRNAs in Human Colorectal Cancer Cells
Cancer cells alter glucose metabolism to support their uncontrolled proliferation. Changes in microRNAs (miRNAs) have been associated with colorectal cancer (CRC) development and progression, but it is not clear whether they regulate metabolism in CRC … Continue reading
Mutation spectrum and risk of colorectal cancer in African American families with Lynch Syndrome
African Americans (AAs) have the highest incidence and mortality of colorectal cancer (CRC) in the United States (US). Few data are available on genetic and non-genetic risk factors for CRC among AAs. Little is known about cancer risks and mutations in… Continue reading
Mutation spectrum and risk of colorectal cancer in African American families with Lynch Syndrome
African Americans (AAs) have the highest incidence and mortality of colorectal cancer (CRC) in the United States (US). Few data are available on genetic and non-genetic risk factors for CRC among AAs. Little is known about cancer risks and mutations in… Continue reading
Analysis of Dysplasia in Patients with Barrett’s Esophagus Based on Expression Pattern of 90 Genes
Diagnoses of dysplasia, based on histologic analyses, dictate management decisions for patients with Barrett’s esophagus (BE). However, there is much intra- and inter-observer variation in identification of dysplasia—particularly low-grade dysplasia … Continue reading