Daily Archives: November 12, 2015

Heterozygous Mutations in BMP6 Pro-peptide Lead to Inappropriate Hepcidin Synthesis and Moderate Iron Overload in Humans

Posted on November 12, 2015 by Raed Daher, Caroline Kannengiesser, Dounia Houamel, Thibaud Lefebvre, Edouard Bardou-Jacquet, Nicolas Ducrot, Caroline de Kerguenec, Anne-Marie Jouanolle, Anne-Marie Robreau, Claire Oudin, Gerald Le Gac, Boualem Moulouel, Veronique Loustaud-Ratti, Pi

Hereditary hemochromatosis is a heterogeneous group of genetic disorders characterized by parenchymal iron overload. It is caused by defective expression of liver hepcidin, the main regulator of iron homeostasis. Iron stimulates the gene encoding (HAMP… Continue reading →

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TLR4 Signaling via NANOG Cooperates With STAT3 to Activate and Promote Formation of Tumor-initiating Stem-like Cells in Livers of Mice

Posted on November 12, 2015 by Dinesh Babu Uthaya Kumar, Chia-Lin Chen, Jian-Chang Liu, Douglas E. Feldman, Linda S. Sher, Samuel French, Joseph DiNorcia, Samuel W. French, Bita V. Naini, Sunhawit Junrungsee, Vatche Garen Agopian, Ali Zarrinpar, Keigo Machida

Obesity and alcohol consumption contribute to steatohepatitis, which increases risk for hepatitis C virus (HCV)-associated hepatocellular carcinomas (HCCs). Mice Hepatocytes that express HCV-NS5A in liver upregulate expression of Toll-like receptor-4 (… Continue reading →

Posted in News | Comments Off on TLR4 Signaling via NANOG Cooperates With STAT3 to Activate and Promote Formation of Tumor-initiating Stem-like Cells in Livers of Mice

Heterozygous Mutations in BMP6 Pro-peptide Lead to Inappropriate Hepcidin Synthesis and Moderate Iron Overload in Humans

Posted on November 12, 2015 by Raed Daher, Caroline Kannengiesser, Dounia Houamel, Thibaud Lefebvre, Edouard Bardou-Jacquet, Nicolas Ducrot, Caroline de Kerguenec, Anne-Marie Jouanolle, Anne-Marie Robreau, Claire Oudin, Gerald Le Gac, Boualem Moulouel, Veronique Loustaud-Ratti, Pi

Hereditary hemochromatosis is a heterogeneous group of genetic disorders characterized by parenchymal iron overload. It is caused by defective expression of liver hepcidin, the main regulator of iron homeostasis. Iron stimulates the gene encoding hepci… Continue reading →

Posted in News | Comments Off on Heterozygous Mutations in BMP6 Pro-peptide Lead to Inappropriate Hepcidin Synthesis and Moderate Iron Overload in Humans

TLR4 Signaling via NANOG Cooperates With STAT3 to Activate and Promote Formation of Tumor-Initiating Stem-Like Cells in Livers of Mice

Posted on November 12, 2015 by Dinesh Babu Uthaya Kumar, Chia-Lin Chen, Jian-Chang Liu, Douglas E. Feldman, Linda S. Sher, Samuel French, Joseph DiNorcia, Samuel W. French, Bita V. Naini, Sunhawit Junrungsee, Vatche Garen Agopian, Ali Zarrinpar, Keigo Machida

Obesity and alcohol consumption contribute to steatohepatitis, which increases the risk for hepatitis C virus (HCV)-associated hepatocellular carcinomas (HCCs). Mouse hepatocytes that express HCV-NS5A in liver up-regulate the expression of Toll-like re… Continue reading →

Posted in News | Comments Off on TLR4 Signaling via NANOG Cooperates With STAT3 to Activate and Promote Formation of Tumor-Initiating Stem-Like Cells in Livers of Mice