Daily Archives: November 18, 2015
Time to Replace Assessment of Liver Histology With MR-Based Imaging Tests to Assess Efficacy of Interventions for Nonalcoholic Fatty Liver Disease
Nonalcoholic fatty liver disease (NAFLD) is the most common metabolic liver disease worldwide and the burden of NAFLD is likely to increase with the epidemic of obesity and type 2 diabetes. The term NAFLD embraces a spectrum of fat-related liver condit… Continue reading
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End Points Must Be Clinically Meaningful for Drug Development in Nonalcoholic Fatty Liver Disease
Nonalcoholic fatty liver disease (NAFLD) has emerged as a major cause of chronic liver disease in many parts of the world. It is associated with increased mortality owing to cardiovascular and liver disease and is also associated with an increased risk… Continue reading
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Liver X Receptor Regulates Triglyceride Absorption Through Intestinal Downregulation of Scavenger Receptor Class B, Type 1
Reducing post-prandial triglyceridemia may be a promising strategy to lower risk of cardiovascular disorders associated with obesity and type 2 diabetes. In enterocytes, scavenger receptor class B, type 1 (SR-B1, encoded by SCARB1) mediates lipid-micel… Continue reading
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Where Do We Stand With Aspirin for the Prevention of Colorectal Cancer? The USPSTF Recommendations
In 2007, the United States Preventive Services Task Force (USPSTF) recommended against the routine use of aspirin for the prevention of colorectal cancer (CRC). However, in September 2015, the USPSTF reversed this stand in its updated draft guidelines and provided low-dose aspirin (pragmatically, 81 mg/d in the United States) with a grade “B” recommendation for chronic disease prophylaxis, including CRC prevention, among US adults between ages 50 and 59 with a >10% 10-year risk of cardiovascular (CVD) events. Continue reading
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Depression and Somatization are Associated with Increased Postprandial Symptoms in Patients With Irritable Bowel Syndrome
Patients with irritable bowel syndrome (IBS) have increased postprandial symptom responses and more psychosocial morbidities than healthy individuals. However, the relationship between psychosocial status and postprandial symptom responses has not been… Continue reading
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Liver X Receptor Regulates Triglyceride Absorption Through Intestinal Down-Regulation of Scavenger Receptor Class B, Type 1
Reducing postprandial triglyceridemia may be a promising strategy to lower the risk of cardiovascular disorders associated with obesity and type 2 diabetes. In enterocytes, scavenger receptor class B, type 1 (SR-B1, encoded by SCARB1) mediates lipid-mi… Continue reading
Posted in News
Comments Off on Liver X Receptor Regulates Triglyceride Absorption Through Intestinal Down-Regulation of Scavenger Receptor Class B, Type 1
Depression and Somatization Are Associated With Increased Postprandial Symptoms in Patients With Irritable Bowel Syndrome
Patients with irritable bowel syndrome (IBS) have increased postprandial symptom responses and more psychosocial morbidities than healthy individuals. However, the relationship between psychosocial status and postprandial symptom responses has not been… Continue reading
Posted in News
Comments Off on Depression and Somatization Are Associated With Increased Postprandial Symptoms in Patients With Irritable Bowel Syndrome
Time to Replace Assessment of Liver Histology With MR-Based Imaging Tests to Assess Efficacy of Interventions for Nonalcoholic Fatty Liver Disease
Nonalcoholic fatty liver disease (NAFLD) is the most common metabolic liver disease worldwide and the burden of NAFLD is likely to increase with the epidemic of obesity and type 2 diabetes. The term NAFLD embraces a spectrum of fat-related liver condit… Continue reading
Posted in News
Comments Off on Time to Replace Assessment of Liver Histology With MR-Based Imaging Tests to Assess Efficacy of Interventions for Nonalcoholic Fatty Liver Disease
End Points Must Be Clinically Meaningful for Drug Development in Nonalcoholic Fatty Liver Disease
Nonalcoholic fatty liver disease (NAFLD) has emerged as a major cause of chronic liver disease in many parts of the world. It is associated with increased mortality owing to cardiovascular and liver disease and is also associated with an increased risk… Continue reading
Posted in News
Comments Off on End Points Must Be Clinically Meaningful for Drug Development in Nonalcoholic Fatty Liver Disease
Where Do We Stand With Aspirin for the Prevention of Colorectal Cancer? The USPSTF Recommendations
In 2007, the United States Preventive Services Task Force (USPSTF) recommended against the routine use of aspirin for the prevention of colorectal cancer (CRC). However, in September 2015, the USPSTF reversed this stand in its updated draft guidelines and provided low-dose aspirin (pragmatically, 81 mg/d in the United States) with a grade “B” recommendation for chronic disease prophylaxis, including CRC prevention, among US adults between ages 50 and 59 with a >10% 10-year risk of cardiovascular (CVD) events. Continue reading
Posted in News
Comments Off on Where Do We Stand With Aspirin for the Prevention of Colorectal Cancer? The USPSTF Recommendations