Monthly Archives: November 2015
High False-Negative Rate for Nonalcoholic Steatohepatitis in Extreme Obesity
The article by Lassailly et al1 reported on 1540 patients who had undergone a bariatric surgery procedure that included 1489 cases in whom intraoperative liver biopsies were obtained. Surprisingly, histologic nonalcoholic steatohepatitis (NASH) was di… Continue reading
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We thank Volta et al for their interest in our work1 and for their comments and data on the frequency of autoimmune diseases and serum autoantibodies in patients suffering from nonceliac wheat sensitivity (NCWS). These authoritative colleagues have em… Continue reading
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We thank Cui et al for their comments regarding our randomized controlled trial of fecal microbiota transplantation (FMT) for patients with ulcerative colitis (NCT01650038).1 The authors are concerned by the in their view unexpectedly high placebo re… Continue reading
Methodology, Not Concept of Fecal Microbiota Transplantation, Affects Clinical Findings
Two recent randomized controlled trials published in Gastroenterology indicated inconsistent results in the treatment of ulcerative colitis by fecal microbiota transplantation (FMT).1,2 Moayyedi et al1 reported a significant efficacy of FMT in inducin… Continue reading
Early Detection of Alcoholic Liver Disease: Are We a Step Closer?
Alcoholic liver disease (ALD) is a growing cause of liver-related morbidity and mortality worldwide.1 Rates of hazardous drinking are increasing,2 the age of onset of drinking is decreasing, and more women are drinking heavily.2 With better control of … Continue reading
Combination of Pegylated Interferon and Tenofovir for Hepatitis B Treatment: Screening and Counseling of Patients are Warranted
Chronic hepatitis B virus (HBV) infection is a significant cause of global morbidity and mortality, primarily owing to liver cirrhosis and hepatocellular carcinoma (HCC). There are an estimated 240 million persons worldwide with chronic HBV.1 Universal… Continue reading
The Morbidity and Mortality Conference in Gastroenterology and Hepatology: An Important Cornerstone of Patient Safety and Optimal Care
The morbidity and mortality (M&M) conference has evolved considerably in recent years. M&M was originally developed by surgeons and anesthesiologists to investigate negative “end results.”1 M&Ms were intended to be an open discussion of error and h… Continue reading
AGA Institute Guideline on the Management of Microscopic Colitis: Clinical Decision Support Tool
The Covalently Closed Circular Form of Hepatitis B Virus Genome: Is There Now an End in “Site”?
One of the major remaining mysteries about the pathogenesis of hepatitis B virus (HBV) infection is how the host immune system resolves the virus infection and eliminates the nuclear form of the viral genome, the covalently closed circular (ccc)DNA. T… Continue reading
Early Detection of Alcoholic Liver Disease: Are We a Step Closer?
Alcoholic liver disease (ALD) is a growing cause of liver-related morbidity and mortality worldwide.1 Rates of hazardous drinking are increasing,2 the age of onset of drinking is decreasing, and more women are drinking heavily.2 With better control of … Continue reading