Monthly Archives: November 2015

Chronic hepatitis B virus (HBV) infection is a significant cause of global morbidity and mortality, primarily owing to liver cirrhosis and hepatocellular carcinoma (HCC). There are an estimated 240 million persons worldwide with chronic HBV.1 Universal… Continue reading →

The morbidity and mortality (M&M) conference has evolved considerably in recent years. M&M was originally developed by surgeons and anesthesiologists to investigate negative “end results.”1 M&Ms were intended to be an open discussion of error and h… Continue reading →

One of the major remaining mysteries about the pathogenesis of hepatitis B virus (HBV) infection is how the host immune system resolves the virus infection and eliminates the nuclear form of the viral genome, the covalently closed circular (ccc)DNA. T… Continue reading →

We thank Sood et al for their interest in our recent large scale validation of plasma anti-CdtB and antivinculin as biomarkers for the diagnosis of irritable bowel syndrome (IBS) with diarrhea. The authors point out strengths and limitations of our st… Continue reading →

Colorectal cancer (CRC) is an important preventable malignancy, with >1 million prevalent cases and >50,000 annual attributable deaths in the United States alone.1 Fortunately, CRC deaths can be prevented with screening.2,3 However, currently available screening tests are imperfect and not without risk, and screening cannot prevent all CRC owing to access issues and other limitations. Screening is also a form of secondary prevention, working to detect cancers after they have already formed. Continue reading →

The inflammatory bowel diseases (IBD) are contemporary diseases of modern societies. Ulcerative colitis emerged in the Western world in the 19th century with “regional ileitis” entering the medical vernacular in the 1930s.1 Throughout the 20th cent… Continue reading →

We thank Sood et al for their interest in our recent large scale validation of plasma anti-CdtB and antivinculin as biomarkers for the diagnosis of irritable bowel syndrome (IBS) with diarrhea. The authors point out strengths and limitations of our st… Continue reading →

Colorectal cancer (CRC) is an important preventable malignancy, with >1 million prevalent cases and >50,000 annual attributable deaths in the United States alone.1 Fortunately, CRC deaths can be prevented with screening.2,3 However, currently available screening tests are imperfect and not without risk, and screening cannot prevent all CRC owing to access issues and other limitations. Screening is also a form of secondary prevention, working to detect cancers after they have already formed. Continue reading →

The inflammatory bowel diseases (IBD) are contemporary diseases of modern societies. Ulcerative colitis emerged in the Western world in the 19th century with “regional ileitis” entering the medical vernacular in the 1930s.1 Throughout the 20th cent… Continue reading →