Monthly Archives: November 2015
Depression and Somatization Are Associated With Increased Postprandial Symptoms in Patients With Irritable Bowel Syndrome
Patients with irritable bowel syndrome (IBS) have increased postprandial symptom responses and more psychosocial morbidities than healthy individuals. However, the relationship between psychosocial status and postprandial symptom responses has not been… Continue reading
Time to Replace Assessment of Liver Histology With MR-Based Imaging Tests to Assess Efficacy of Interventions for Nonalcoholic Fatty Liver Disease
Nonalcoholic fatty liver disease (NAFLD) is the most common metabolic liver disease worldwide and the burden of NAFLD is likely to increase with the epidemic of obesity and type 2 diabetes. The term NAFLD embraces a spectrum of fat-related liver condit… Continue reading
End Points Must Be Clinically Meaningful for Drug Development in Nonalcoholic Fatty Liver Disease
Nonalcoholic fatty liver disease (NAFLD) has emerged as a major cause of chronic liver disease in many parts of the world. It is associated with increased mortality owing to cardiovascular and liver disease and is also associated with an increased risk… Continue reading
Where Do We Stand With Aspirin for the Prevention of Colorectal Cancer? The USPSTF Recommendations
In 2007, the United States Preventive Services Task Force (USPSTF) recommended against the routine use of aspirin for the prevention of colorectal cancer (CRC). However, in September 2015, the USPSTF reversed this stand in its updated draft guidelines and provided low-dose aspirin (pragmatically, 81 mg/d in the United States) with a grade “B” recommendation for chronic disease prophylaxis, including CRC prevention, among US adults between ages 50 and 59 with a >10% 10-year risk of cardiovascular (CVD) events. Continue reading
Mushtaq A. Khan, DVM, PhD: Unwavering Supporter for Digestive Diseases Research
After 37 years of distinguished career in government service, Mushtaq Khan recently retired from his position as Scientific Review Officer (SRO) of the Clinical, Integrative and Molecular Gastroenterology (CIMG) Study Section of the Center for Scientif… Continue reading
Mushtaq A. Khan, DVM, PhD: Unwavering Supporter for Digestive Diseases Research
After 37 years of distinguished career in government service, Mushtaq Khan recently retired from his position as Scientific Review Officer (SRO) of the Clinical, Integrative and Molecular Gastroenterology (CIMG) Study Section of the Center for Scientif… Continue reading
Managing Microscopic Colitis: A Patient Guide
Microscopic colitis is a condition of the colon that causes watery diarrhea, pain, and nausea. It is more common among people older than 60 years of age. Budesonide is the most effective treatment and has a low risk of side effects. However, the cost o… Continue reading
American Gastroenterological Association Institute Guideline on the Medical Management of Microscopic Colitis
This document presents the official recommendations of the American Gastroenterological Association (AGA) Institute on the medical management of microscopic colitis. The guideline was developed by the AGA Clinical Guidelines Committee and approved by t… Continue reading
Virus-specific CD4+ T Cells Have Functional and Phenotypic Characteristics of Follicular T-helper Cells in Patients With Acute and Chronic HCV Infections
Follicular T-helper (Tfh) cells contribute to pathogen-specific antibody responses by providing maturation signals to B cells. In mice with viral infections, virus-specific Tfh cells expand and are required to contain the infection. However, less is kn… Continue reading
Risk of Advanced Adenomas in Siblings of Individuals with Advanced Adenomas: A Cross-sectional Study
The risk of colorectal neoplasms among siblings of individuals with advanced adenomas is not clear. We determined the prevalence of advanced adenomas in siblings of subjects with advanced adenomas and compared it to siblings of subjects without these l… Continue reading